-
Article
Open AccessTNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level
The relationship between schizophrenia (SCZ) and cancer development remains controversial. Based on the disease-gene association platform, it has been revealed that tumor necrosis factor receptor (TNFR) could ...
-
Article
Open AccessSignificance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various in...
-
Article
Open AccessMesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Faslpr mice
Nephritis is common in systemic lupus erythematosus patients and is associated with hyper-activation of immune and renal cells. Although mesenchymal stem cells (MSCs) ameliorate nephritis by inhibiting T and B...
-
Article
Open AccessCHI3L1 induces autophagy through the JNK pathway in lung cancer cells
CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and death. According to recent research, autophagy regulates tumor growth during various stages of cancer development. Th...
-
Article
Overexpression of transmembrane TNFα in brain endothelial cells induces schizophrenia-relevant behaviors
Upregulation of genes and coexpression networks related to immune function and inflammation have been repeatedly reported in the brain of individuals with schizophrenia. However, a causal relationship between ...
-
Article
Open AccessAnti-skin aging activity of eggshell membrane administration and its underlying mechanism
There is active research on develo** materials for improving skin function. Eggshell membrane (ESM) is one such raw material that is consumed as a functional food to support skin health. However, studies on ...
-
Article
Open AccessAmyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120
Human immunodeficiency virus 1 (HIV-1) infection can cause several HIV-associated neurocognitive disorders a variety of neurological impairments characterized by the loss of cortical and subcortical neurons an...
-
Article
Open AccessK284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cycloh...
-
Article
Open AccessAntifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS
Alzheimer’s disease (AD) is closely related to neuroinflammation, and the increase in inflammatory cytokine generation and inducible nitric oxide synthase (iNOS) expression in the brain of a patient with AD is...
-
Article
Open AccessPRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal
Impaired neurogenesis has been associated with several brain disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The role of peroxiredoxin 6 (PRDX6) in neurodegenerative diseases is very ...
-
Article
Open AccessPiperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway
Amyloidogenesis is known to cause Alzheimer’s disease. Our previous studies have found that lipopolysaccharide (LPS) causes neuroinflammation and amyloidogenesis through activation of nuclear factor kappaB (NF...
-
Article
Open AccessIL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation
The low expression of tissue inhibitor of metalloproteinase 3 (TIMP-3) is important in inflammatory responses. Therefore, inhibition of TIMP-3 may promote tumor development. Our study showed that expression of...
-
Article
Open AccessNovel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3
Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 (STAT3)-targeted small molecules have sh...
-
Article
Open AccessPiperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there has been no study regarding the mechanisms of PL on the lung cancer yet. Thus, we evaluated the a...
-
Article
Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal
The purpose of this study was to evaluate the enhancing potency of tectochrysin, a flavonoid isolated from Alpinia oxyphylla Miquel by combining cetuximab, an anti-EGFR monoclonal antibody, on human colon canc...
-
Article
Open AccessBee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway
Accumulation of beta-amyloid and neuroinflammation trigger Alzheimer’s disease. We previously found that lipopolysaccharide (LPS) caused neuroinflammation with concomitant accumulation of beta-amyloid peptides...
-
Article
Open AccessCDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma
Comparative genetic and biological studies on malignant tumor counterparts in human beings and laboratory mice may be powerful gene discovery tools for blood cancers, including neoplasms of mature B-lymphocyte...
-
Article
Open AccessFlow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), in part, due to alterations in gene expression in the endothelium. While numerous in vitro studies have shown ho...
-
Article
The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis
MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is still unclear. Here we identify miRNA-712 (miR-712) as a mechanosensitive miRNA up...
-
Article
Open AccessNF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma
Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocation is the recognized hallmark of Burkitt lymphoma, an aggressive form of non-Hodgkin's lymphoma. We developed a model th...
