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Article
Structural basis for the tethered peptide activation of adhesion GPCRs
Adhesion G-protein-coupled receptors (aGPCRs) are important for organogenesis, neurodevelopment, reproduction and other processes1–6. Many aGPCRs are activated by a conserved internal (tethered) agonist sequence ...
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Article
Open AccessThe important effect of 5-HTTLPR polymorphism on the risk of depression in patients with coronary heart disease: a meta-analysis
Depression has been recognized as an independent risk factor of coronary heart disease (CHD). Moreover, there is interrelationship of both depression and CHD. However, the potential pathophysiological mechanis...
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Article
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs ...
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Article
Open AccessArrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules t...
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Article
Open AccessPhospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR
Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino acid incorporation and fluori...
