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    Article

    Current Challenges and Controversies in Drug-Induced Liver Injury

    Current key challenges and controversies encountered in the identification of potentially hepatotoxic drugs and the assessment of drug-induced liver injury (DILI) are covered in this article.

    Alberto Corsini, Patricia Ganey, Cynthia Ju, Neil Kaplowitz… in Drug Safety (2012)

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    Chapter

    Mitochondrial Involvement in Drug-Induced Liver Injury

    Mitochondrial dysfunction is a major mechanism of liver injury. A parent drug or its reactive metabolite can trigger outer mitochondrial membrane permeabilization or rupture due to mitochondrial permeability t...

    Dominique Pessayre, Abdellah Mansouri, Alain Berson… in Adverse Drug Reactions (2010)

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    Chapter

    Drug-Induced Microvesicular Steatosis and Steatohepatitis

    Dominique Pessayre, Bernard Fromenty, Abdellah Mansouri in Mitochondria in Pathogenesis (2002)

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    Chapter

    Human Epoxide Hydrolase is the Target of Germander Autoantibodies on the Surface of Human Hepatocytes: Enzymatic Implications

    Western countries observed an increased interest for the use of herbal medicines because of their supposed safety in contrast to chemical drugs. Wild germander (Teuchrium chamaedrys L) was traditionally used as a...

    Jacqueline Loeper, Veronique De Berardinis… in Biological Reactive Intermediates VI (2001)

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    Article

    Hepatotoxicity of Antitubercular Treatments

    The standard antitubercular regimen currently includes a combination of 3 antitubercular agents: isoniazid, rifampicin (rifampin) and pyrazinamide. Administration of a fourth agent, ethambutol, is recommended ...

    Dr François Durand, Gilles Jebrak, Dominique Pessayre, Michel Fournier… in Drug Safety (1996)

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    Article

    Most cases of medium-chain acyl-CoA dehydrogenase deficiency escape detection in France

    DNA from 414 French blood donors from the Paris area was assessed for the A985G mutation responsible for most cases of autosomal recessive medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. The mutant gene...

    Bernard Fromenty, Abdellah Mansouri, Jean-Paul Bonnefont… in Human Genetics (1996)

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    Article

    Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin

    The HMG-CoA reductase inhibitor, lovastatin, is known to induce asymptomatic liver dysfunction in a few patients. We report the case of an adult who suffered from clinical hepatitis three months after the onse...

    Sylvie Grimbert, Dominique Pessayre, Claude Degott… in Digestive Diseases and Sciences (1994)

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    Article

    Pancreatic Cholera (W.D.H.A. syndrome)

    Results of light- and electron-microscopic studies of a primary pancreatic tumor and of metastasis in a new case of Pancreatic Cholera (P.C.) are reported. The primary tumor, but not the metastases, contained unu...

    Jean-Claude Rambaud, Annie Galian, Jacques Scotto, Pierre Hautefeuille… in Virchows Archiv A (1975)