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within Dominik Aschenbrenner Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter Science, multidisciplinary Remove this filter

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  1. Article

    Open Access

    An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn’s disease with defective antimicrobial activity

    Despite major advances in linking single genetic variants to single causal genes, the significance of genetic variation on transcript-level regulation of expression, transcript-specific functions, and relevanc...

    Dominik Aschenbrenner, Isar Nassiri, Suresh Venkateswaran… in Nature Communications (2024)

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  2. Article

    Open Access

    Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

    We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (T

    Dan Hu, Samuele Notarbartolo, Tom Croonenborghs, Bonny Patel… in Nature Communications (2017)

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  3. No Access

    Article

    ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells

    T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we...

    Federico Mele, Camilla Basso, Cristina Leoni… in Nature Communications (2015)

  4. No Access

    Article

    Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

    Infection with Candida albicans and Staphylococcus aureus gives rise to TH17 cells with different properties; microbe-induced T-cell differentiation is shown here to depend on the balance between polarizing cytok...

    Christina E. Zielinski, Federico Mele, Dominik Aschenbrenner, David Jarrossay… in Nature (2012)