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  1. No Access

    Article

    Metabolic modulation of tumours with engineered bacteria for immunotherapy

    The availability of l-arginine in tumours is a key determinant of an efficient anti-tumour T cell response1–4. Consequently, increases of typically low l-arginine concentrations within the tumour may greatly pote...

    Fernando P. Canale, Camilla Basso, Gaia Antonini, Michela Perotti, Ning Li… in Nature (2021)

  2. Article

    Open Access

    Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

    CD4+ Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of ...

    Francesca Ronchi, Camilla Basso, Silvia Preite, Andrea Reboldi… in Nature Communications (2016)

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  3. No Access

    Article

    ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells

    T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we...

    Federico Mele, Camilla Basso, Cristina Leoni… in Nature Communications (2015)