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  1. Article

    Open Access

    The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

    Mechanosignaling, initiated by extracellular forces and propagated through the intracellular cytoskeletal network, triggers signaling cascades employed in processes as embryogenesis, tissue maintenance and dis...

    Divya Purushothaman, Laura F. Bianchi, Dmitry Penkov… in Communications Biology (2022)

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  2. Article

    Open Access

    PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

    The synthesis of middle-to-late-replicating DNA can be affected independently of the rest of the genome by down-regulating the tumor suppressor PREP1 (PKNOX1). Indeed, DNA combing shows that PREP1 down-regulat...

    Angela Palmigiano, Francesco Santaniello, Aurora Cerutti… in Scientific Reports (2018)

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  3. Article

    Open Access

    Prep1 prevents premature adipogenesis of mesenchymal progenitors

    Transcriptional regulators are crucial in adipocyte differentiation. We now show that the homeodomain-containing transcription factor Prep1 is a repressor of adipogenic differentiation since its down-regulatio...

    Giorgia Maroni, Vsevolod A. Tkachuk, Alexander Egorov… in Scientific Reports (2017)

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  4. Article

    PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice

    The aim of this study was to investigate the function of Prep1 (also known as Pknox1) in hepatic lipogenesis.

    Francesco Oriente, Serena Cabaro, Antonietta Liotti, Michele Longo… in Diabetologia (2013)

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