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Open AccessTargeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune ther...
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Open AccessExploring the pre-immune landscape of antigen-specific T cells
Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequen...
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Open AccesstcR: an R package for T cell receptor repertoire advanced data analysis
The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in antigen recognition during the adaptive immune response. Recent progress in next-generation sequencing technologies has provided an o...
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Article
Open AccessOptogenetic in vivocell manipulation in KillerRed-expressing zebrafish transgenics
KillerRed (KR) is a novel photosensitizer that efficiently generates reactive oxygen species (ROS) in KR-expressing cells upon intense green or white light illumination in vitro, resulting in damage to their plas...
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Article
Open AccessInterconversion of Anthozoa GFP-like fluorescent and non-fluorescent proteins by mutagenesis
Within the family of green fluorescent protein (GFP) homologs, one can mark two main groups, specifically, fluorescent proteins (FPs) and non-fluorescent or chromoproteins (CPs). Structural background of diffe...
