3 Result(s)
within
Dmitry M. Chudakov
Biomedicine
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Article
Open AccessTargeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune ther...
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Article
An overview of immunoinformatics approaches and databases linking T cell receptor repertoires to their antigen specificity
Recent advances in molecular and bioinformatic methods have greatly improved our ability to study the formation of an adaptive immune response towards foreign pathogens, self-antigens, and cancer neoantigens. ...
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Article
Open AccessExploring the pre-immune landscape of antigen-specific T cells
Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequen...
