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Protocol
Fate Map** of Cancer Cells in Metastatic Lymph Nodes Using Photoconvertible Proteins
The lymph node microenvironment is extremely dynamic and responds to immune stimuli in the host by reprogramming immune, stromal, and endothelial cells. In normal physiological conditions, the lymph node will ...
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Article
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
In Fig. 4e of this Article, the labels for ‘Control’ and ‘HFD’ were reversed (‘Control’ should have been labelled blue rather than purple, and ‘HFD’ should have been labelled purple rather than blue). Similarl...
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Article
Correction: Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Nat. Biotechnol. 35, 569–576 (2017); published online 1 May 2017; corrected after print 6 July 2017 In the version of this article initially published, the initial “J” was omitted from an author's name, which ...
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Article
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.
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Article
Open AccessASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial
Although aspirin is recommended for the prevention of colorectal cancer, the specific individuals for whom the benefits outweigh the risks are not clearly defined. Moreover, the precise mechanisms by which asp...
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Article
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cell...
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Protocol
The Use of Fluorescent Proteins for Intravital Imaging of Cancer Cell Invasion
The analysis of cancer cell behavior in the primary tumor in living animals provides an opportunity to explore the process of invasion and intravasation in the complex microenvironment that is present in vivo....
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Article
Intravital imaging of metastatic behavior through a mammary imaging window
The combination of a glass window placed on top of a mouse mammary gland with photoswitchable fluorescent protein labeling of implanted tumor cells allows tumor-cell tracking over multiple imaging sessions in ...
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Article
Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis
Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be “hijacked”...
