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Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery
Several diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study is a head-to-head comparison of the performance of the Assessment of D...
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Open AccessMachine learning and radiomics for segmentation and classification of adnexal masses on ultrasound
Ultrasound-based models exist to support the classification of adnexal masses but are subjective and rely upon ultrasound expertise. We aimed to develop an end-to-end machine learning (ML) model capable of aut...
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Article
Open AccessMulticlass risk models for ovarian malignancy: an illustration of prediction uncertainty due to the choice of algorithm
Assessing malignancy risk is important to choose appropriate management of ovarian tumors. We compared six algorithms to estimate the probabilities that an ovarian tumor is benign, borderline malignant, stage ...
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Article
Open AccessNucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer
Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions of cell types contributing to cfDNA. Based on cfDNA fragmentation patterns, the deviation in nucleosome footprin...
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Open AccessAdaptive sample size determination for the development of clinical prediction models
We suggest an adaptive sample size calculation method for develo** clinical prediction models, in which model performance is monitored sequentially as new data comes in.
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Open AccessOrganoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review
Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer in developed countries, indicating the need for further research. Although current cancer models prove useful, they have major limit...
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Article
Open AccessThree myths about risk thresholds for prediction models
Clinical prediction models are useful in estimating a patient’s risk of having a certain disease or experiencing an event in the future based on their current characteristics. Defining an appropriate risk thre...
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Open AccessSex differences in fetal growth and immediate birth outcomes in a low-risk Caucasian population
According to the WHO Multicentre Growth Reference Study Group recommendations, boys and girls have different growth trajectories after birth. Our aim was to develop gender-specific fetal growth curves in a low...
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Article
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering scientific and clinical progress. H...
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Article
Open AccessImplementing robotic assisted myomectomy in surgical practice – a retrospective cohort study
To compare surgical outcomes of patients with leiomyomas after robotic-assisted laparoscopic myomectomy (RALM), laparoscopic myomectomy (LsM), or laparotomic myomectomy (LtM) and to construct a useful algorith...
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Article
Open AccessElective uterine artery embolization prior to laparoscopic resection of interstitial pregnancy: two cases and literature review
Interstitial pregnancies (IP) can be treated medically or surgically. The most common complication remains hemorrhage. The risk of that may be reduced by elective uterine artery embolization (UAE) prior to sur...
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Article
Open AccessIs a motivational interviewing based lifestyle intervention for obese pregnant women across Europe implemented as planned? Process evaluation of the DALI study
Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of g...
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Open AccessErratum to: Methods for evaluating medical tests and biomarkers
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Open AccessMethods for Evaluating Medical Tests and Biomarkers
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Open AccessPhysical activity, depressed mood and pregnancy worries in European obese pregnant women: results from the DALI study
The purpose of this study was to examine the association between mental health status (i.e. depressed mood and pregnancy-related worries) and objectively measured physical activity levels in obese pregnant wom...
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Article
Hysterosal**o-foam sonography (HyFoSy) using two different balloon catheters: a randomized trial
The purposes of this study were to evaluate and compare the technical feasibility and the patients’ pain during hysterosal**o-foam sonography (HyFoSy) using two different 2-mm balloon catheters. Randomized t...
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Article
Open AccessPreoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) – a study of the TOC Consortium
Borderline tumors of the ovary (BOT) are a distinct entity of ovarian tumors, characterized by lack of stromal invasion. Recent studies postulated that the presence of invasive implants, incomplete staging, fe...
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Article
Ultrasound examination before, during, and after office endometrial sampling
Office endometrial sampling is widely used as the first diagnostic test in women with abnormal uterine bleeding. Because office sampling is a blind procedure, the lesion causing the symptoms may be missed. The...
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Article
Open AccessPeritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery
To translate the concept of full-conditioning (FC) from animal experiments to the human, and to evaluate the efficacy for adhesion prevention. FC consisted of decreasing acute inflammation by 86% CO2+ 10% N2O + 4...
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Article
Open AccessScreening for data clustering in multicenter studies: the residual intraclass correlation
In multicenter studies, center-specific variations in measurements may arise for various reasons, such as low interrater reliability, differences in equipment, deviations from the protocol, sociocultural chara...
