12 Result(s)

Article

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma

TBX3 behaves as a tumor suppressor or oncoprotein across cancer. However, TBX3 function remains undetermined in intrahepatic cholangiocarcinoma (iCCA), a deadly primary liver malignancy with few systemic treat...

Shanshan Deng, **njun Lu, Xue Wang, Binyong Liang, Hongwei Xu… in Cell Death & Disease (2024)

Article

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in

Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang… in Cell Death & Disease (2023)

Article

A new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors

Weiting Liao, Diego F. Calvisi, **n Chen in Signal Transduction and Targeted Therapy (2023)

Article

Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common primary cancer with an unsatisfactory long-term survival. Gain of function mutations of PIK3CA occur in a subset of human HCC. Alpelisib, a selective PIK3CA...

Hongwei Xu, Kefei Chen, Runze Shang, **nyan Chen, Yi Zhang… in Cell Death & Disease (2021)

Article

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Dysregulation of transforming growth factor-beta (TGFβ) signaling has been implicated in liver carcinogenesis with both tumor promoting and inhibiting activities. Activation of the c-MYC protooncogene is anoth...

Haichuan Wang, Pan Wang, Meng Xu, **nhua Song, Hong Wu… in Cell Death & Disease (2021)

Article

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

Intrahepatic cholangiocarcinoma (iCCA) is a deadly disease with rising incidence and few treatment options. An altered expression and/or activation of NOTCH1–3 receptors has been shown to play a role in iCCA d...

Serena Mancarella, Grazia Serino, Francesco Dituri… in Cell Death & Differentiation (2020)

Article

Oncogene-dependent function of BRG1 in hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key comp...

Pan Wang, **nhua Song, Dan Cao, Kairong Cui, **gxiao Wang… in Cell Death & Disease (2020)

Article

Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of kar...

Elisabeth Drucker, Kerstin Holzer, Stefan Pusch… in Cell Communication and Signaling (2019)

Article

MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment

PD901, a MEK inhibitor, has been demonstrated of therapeutic efficacy against cholangiocarcinoma (CCA) harboring K-Ras oncogenic mutations. However, most CCA exhibit no K-Ras mutations. In the current study, we i...

Pan Wang, **nhua Song, Kirsten Utpatel, Runze Shang, Yoon Mee Yang… in Cell Death & Disease (2019)

Article

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with po...

**gxiao Wang, Mingjie Dong, Zhong Xu, **nhua Song, Shanshan Zhang, Yu Qiao… in Oncogene (2018)

Article

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model

Intrahepatic cholangiocarcinoma (iCCA) is a deadly malignancy with limited treatment options. Gain-of-function mutations in K-Ras is a very frequent alteration, occurring in ~15 to 25% of human iCCA patients. Her...

Mingjie Dong, **anqiong Liu, Katja Evert, Kirsten Utpatel… in Cell Death & Disease (2018)