6 Result(s)

Article

Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis

Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hith...

Sophie Klemm, Katja Evert, Kirsten Utpatel, Alexandra Muggli, Maria M. Simile… in BMC Cancer (2023)

Article

A new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors

Weiting Liao, Diego F. Calvisi, **n Chen in Signal Transduction and Targeted Therapy (2023)

Article

Functional role of SGK3 in PI3K/Pten driven liver tumor development

Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

Hui Cao, Zhong Xu, **gxiao Wang, Antonio Cigliano, Maria G. Pilo… in BMC Cancer (2019)

Article

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...

Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga… in BMC Cancer (2018)

Article

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with po...

**gxiao Wang, Mingjie Dong, Zhong Xu, **nhua Song, Shanshan Zhang, Yu Qiao… in Oncogene (2018)