11 Result(s)
within
Diego F. Calvisi
English
Medicine/Public Health, general
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Article
Open AccessIdentification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hith...
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Article
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. The...
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Article
Open AccessA new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors
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Article
Open AccessCholangiocarcinoma 2020: the next horizon in mechanisms and management
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~...
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Article
Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common form of primary adult liver cancer. After nearly a decade with sorafenib as the only approved treatment, multiple new agents have demonstrated efficacy in clin...
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Article
Publisher Correction: Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessFunctional role of SGK3 in PI3K/Pten driven liver tumor development
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...
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Article
Open AccessOncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...
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Article
Open AccessNotch2 controls hepatocyte-derived cholangiocarcinoma formation in mice
Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with po...
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Article
Open AccessCholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Cholangiocarcinomas are a heterogeneous group of bile duct cancers and the second most common primary liver tumour worldwide. In this Consensus statement, the newly formed European Network for the Study of Cho...
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Article
Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice
The micronutrient element selenium (Se) has been shown to be effective in reducing the incidence of cancer in animal models and human clinical trials. Selenoproteins and low molecular weight Se compounds were ...
