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Article
Open AccessInhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling
Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transformin...
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Living Reference Work Entry In depth
Animal Models of PAH and Increased Pulmonary Blood Flow
Pulmonary arterial hypertension (PAH), a progressive pulmonary arteriopathy, is characterized by the development of characteristic neointimal lesions including concentric laminar intimal fibrosis and plexiform...