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  1. Article

    Open Access

    Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

    Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transformin...

    Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen… in Angiogenesis (2022)

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  2. No Access

    Living Reference Work Entry In depth

    Animal Models of PAH and Increased Pulmonary Blood Flow

    Pulmonary arterial hypertension (PAH), a progressive pulmonary arteriopathy, is characterized by the development of characteristic neointimal lesions including concentric laminar intimal fibrosis and plexiform...

    Michael G. Dickinson… in Pediatric and Congenital Cardiology, Cardi…