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Open AccessAuthor Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessIntegrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotate...
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Intron retention is a source of neoepitopes in cancer
Neoepitopes derived from intron retention events are processed and presented on MHC I in cancer cell lines.
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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
Tumor mutational burden correlates with response to immune checkpoint blockade in multiple solid tumors, although in microsatellite-stable tumors this association is of uncertain clinical utility. Here we unif...
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Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1–4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted the...
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Open AccessMutational patterns in chemotherapy resistant muscle-invasive bladder cancer
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matche...
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening appr...
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Open AccessErratum to: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures
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Open AccessTumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures
Tumor-infiltrating immune cells have been linked to prognosis and response to immunotherapy; however, the levels of distinct immune cell subsets and the signals that draw them into a tumor, such as the express...
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Open AccessThe impact of tumor profiling approaches and genomic data strategies for cancer precision medicine
The diversity of clinical tumor profiling approaches (small panels to whole exomes with matched or unmatched germline analysis) may engender uncertainty about their benefits and liabilities, particularly in li...
