![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Genetic variation in LIN28B is associated with the timing of puberty
Ken Ong and colleagues report a genome-wide association study for age at menarche. They find LIN28B associated with age at menarche, as well as several traits related to onset of puberty in both females and males...
-
Article
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung fu...
-
Article
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities
Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportu...
-
Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
-
Article
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conducti...
-
Article
Common variants associated with plasma triglycerides and risk for coronary artery disease
Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development ...
-
Article
Open AccessA BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival
BRCA1 mutation carriers have an 85% risk of develo** breast cancer but the risk of develo** non-hereditary breast cancer is difficult to assess. Our objective is to test whether a DNA methylation (DNAme) sign...
-
Article
Defining the role of common variation in the genomic and biological architecture of adult human height
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci signif...
-
Article
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in bloo...
-
Article
Open AccessCorrelation of an epigenetic mitotic clock with cancer risk
Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be...
-
Article
Open AccessHepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats...
-
Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
-
Article
Open AccessChildhood growth and development and DNA methylation age in mid-life
In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life.
-
Article
Open AccessGenetic impacts on DNA methylation help elucidate regulatory genomic processes
Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk.