6 Result(s)
within
Diana Kuh
Human Genetics
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Article
Open AccessGenetic impacts on DNA methylation help elucidate regulatory genomic processes
Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk.
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Open AccessChildhood growth and development and DNA methylation age in mid-life
In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life.
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Article
Open AccessHepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats...
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Article
Open AccessCorrelation of an epigenetic mitotic clock with cancer risk
Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be...
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Open AccessA BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival
BRCA1 mutation carriers have an 85% risk of develo** breast cancer but the risk of develo** non-hereditary breast cancer is difficult to assess. Our objective is to test whether a DNA methylation (DNAme) sign...
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Article
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities
Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportu...
