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The trans-ancestral genomic architecture of glycemic traits

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  1. Article

    Open Access

    Genetic impacts on DNA methylation help elucidate regulatory genomic processes

    Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk.

    Sergio Villicaña, Juan Castillo-Fernandez, Eilis Hannon in Genome Biology (2023)

  2. Article

    Open Access

    Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption

    Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats...

    Francis W. B. Sanders, Animesh Acharjee, Celia Walker, Luke Marney in Genome Biology (2018)

  3. Article

    Open Access

    Correlation of an epigenetic mitotic clock with cancer risk

    Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be...

    Zhen Yang, Andrew Wong, Diana Kuh, Dirk S. Paul, Vardhman K. Rakyan in Genome Biology (2016)

  4. Article

    The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

    Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportu...

    Jane WY Ng, Laura M Barrett, Andrew Wong, Diana Kuh, George Davey Smith in Genome Biology (2012)