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  1. Article

    Open Access

    The effect of early postnatal auditory stimulation on outcomes in preterm infants

    Preterm infants are deprived of in utero sensory stimulation during the third trimester, an important period of central nervous system development. As a result, maturational trajectories are often reduced in infa...

    Juliann M. Di Fiore, Gloria Liu, Kenneth A. Loparo, Cynthia F. Bearer in Pediatric Research (2024)

  2. Article

    Open Access

    Monitoring Activity and Gait in Children (MAGIC) using digital health technologies

    Digital health technologies (DHTs) can collect gait and physical activity in adults, but limited studies have validated these in children. This study compared gait and physical activity metrics collected using...

    Junrui Di, Pirinka Georgiev Tuttle, Lukas Adamowicz, Wenyi Lin in Pediatric Research (2024)

  3. No Access

    Article

    Maturation of cardioventilatory physiological trajectories in extremely preterm infants

    In extremely preterm infants, persistence of cardioventilatory events is associated with long-term morbidity. Therefore, the objective was to characterize physiologic growth curves of apnea, periodic breathing...

    Debra E. Weese-Mayer, Juliann M. Di Fiore, Douglas E. Lake in Pediatric Research (2024)

  4. No Access

    Article

    Maternal periconceptional folic acid supplementation and risk for fetal congenital genitourinary system defects

    Taking folic acid supplementation could reduce the risk of neural tube defects for offspring in the maternal periconceptional period, but the relationship between folic acid use and other birth defects remains...

    Zixi Pang, Lei **, Jie Zhang, Wenying Meng, Di Wang, Lei ** in Pediatric Research (2024)

  5. No Access

    Article

    Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model

    Recombinant human IGF-1/binding protein-3 (rhIGF-1/BP3) is currently being tested in phase II clinical trials in premature infants to prevent bronchopulmonary dysplasia, but its impact on the neonatal intestin...

    **aocai Yan, Elizabeth Managlia, Galen Carey, Norman Barton in Pediatric Research (2024)

  6. Article

    Open Access

    Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis

    Despite multifactorial pathogenesis, dysregulation of inflammatory immune response may play a crucial role in necrotizing enterocolitis (NEC). Regulatory T cells (Tregs) are involved in immune tolerance early ...

    Ilenia Pacella, Maria Di Chiara, Rita Prota, Chiara De Luca in Pediatric Research (2023)

  7. No Access

    Article

    Hypoxemia events in preterm neonates are associated with urine oxidative biomarkers

    Intermittent hypoxemia (IH) events are common in preterm neonates and are associated with adverse outcomes. Animal IH models can induce oxidative stress. We hypothesized that an association exists between IH a...

    Thomas M. Raffay, Juliann M. Di Fiore, Zhengyi Chen in Pediatric Research (2023)

  8. No Access

    Article

    Plasma serotonergic biomarkers are associated with hypoxemia events in preterm neonates

    Hypoxemia is a physiological manifestation of immature respiratory control in preterm neonates, which is likely impacted by neurotransmitter imbalances. We investigated relationships between plasma levels of t...

    Peter Mathew MacFarlane, Richard John Martin, Juliann Marie Di Fiore in Pediatric Research (2023)

  9. No Access

    Article

    CT-based identification of pediatric non-Wilms tumors using convolutional neural networks at a single center

    Deep learning (DL) is more and more widely used in children’s medical treatment. In this study, we have developed a computed tomography (CT)-based DL model for identifying undiagnosed non-Wilms tumors (nWTs) f...

    Yupeng Zhu, Hailin Li, Yangyue Huang, Wangxing Fu, Siwen Wang in Pediatric Research (2023)

  10. Article

    Open Access

    Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset

    To evaluate (i) the prevalence and association of euthyroid sick syndrome (ESS) [decreased FT3 and/or FT4 and normal/decreased TSH] with severity indexes of type 1 diabetes mellitus (T1DM) onset such as diabet...

    Pierluigi Marzuillo, Dario Iafusco, Stefano Guarino, Anna Di Sessa in Pediatric Research (2023)

  11. Article

    Open Access

    Consequences of gestational diabetes mellitus on neonatal cardiovascular health: MySweetHeart Cohort study

    Hyperglycaemic disorders of pregnancy are associated with offspring cardiovascular alterations.

    Stefano C. Di Bernardo, Sebastiano A. G. Lava, Adina Mihaela Epure in Pediatric Research (2023)

  12. No Access

    Article

    Neurodevelopmental consequences of preterm punctate white matter lesions: a systematic review

    To evaluate punctate white matter lesion (PWML) influence in preterm infants on the long-term neurodevelopmental outcome (NDO).

    Clara Adriana Maria de Bruijn, Stefano Di Michele in Pediatric Research (2023)

  13. No Access

    Article

    Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

    To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive ...

    Carl Bose, Gregory C. Valentine, Kamaira Philips, Kim Boggess in Journal of Perinatology (2023)

  14. Article

    Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels

    Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19. Viral entry requires ACE2 and transmembrane protease serine 2 (TMP...

    Mauro G. Silva, Nora L. Falcoff, Gerardo R. Corradi, Norma Di Camillo in Pediatric Research (2023)

  15. No Access

    Chapter

    Pump Therapy and Use of Technologies

    Neonatal Diabetes Mellitus (NDM) treatment and clinical management still represent a strong challenge for pediatricians and diabetologists. Therefore, many authors have shown increasing interest in the use of ...

    Raffaella Di Tonno, Valeria Castorani in Neonatal and Early Onset Diabetes Mellitus (2023)

  16. No Access

    Chapter

    Abuse, Human Trafficking, and Prostitution

    Human trafficking and sexual exploitation have enormous health consequences. Abusive elements compose part of its definition. Sex work, under certain circumstances, poses a unique occupational challenge to hea...

    Carlo Matteo Di Dionisio, Tommaso B. Jannini in Emotional, Physical and Sexual Abuse (2023)

  17. No Access

    Chapter

    Etiology of Sexual Offending

    To understand the act of sexual offending the considerations, research say, must start earlier in the life of the individual. A variety of factors and their interaction can set off a process as soon as in chil...

    Carlo Matteo Di Dionisio, Tommaso B. Jannini in Emotional, Physical and Sexual Abuse (2023)

  18. No Access

    Article

    Short and long-term outcomes of children with autoimmune congenital heart block treated with a combined maternal-neonatal therapy. A comparison study

    The short and long-term outcomes of children with anti-Ro/La-related congenital heart block treated with a combined maternal-neonatal therapy protocol were compared with those of controls treated with other th...

    Amelia Ruffatti, Alessia Cerutti, Marta Tonello, Maria Favaro in Journal of Perinatology (2022)

  19. No Access

    Article

    Evolution of congenital anomalies of urinary tract in children with and without solitary kidney

    We hypothesized that children with congenital solitary functioning kidney (CSFK) present forms of congenital urinary tract anomalies (CUTA) with higher chance of spontaneous resolution compared with patients w...

    Pierluigi Marzuillo, Stefano Guarino, Anna Di Sessa, Laura Liguori in Pediatric Research (2022)

  20. No Access

    Article

    Neuroimaging and neurodevelopmental outcome after early fetal growth restriction: NEUROPROJECT—FGR

    Adverse neurodevelopmental outcomes and MRI alterations are reported in infants born after fetal growth restriction (FGR). This study evaluates the additional role of FGR over prematurity in determining brain ...

    Gloria Brembilla, Andrea Righini, Barbara Scelsa, Gianluca Lista in Pediatric Research (2021)

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