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Article
Open AccessIn-situ noncovalent interaction of ammonium ion enabled C–H bond functionalization of polyethylene glycols
The noncovalent interactions of ammonium ion with multidentate oxygen-based host has never been reported as a reacting center in catalytic reactions. In this work, we report a reactivity enhancement process en...
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Article
Open AccessEngineering siRNA therapeutics: challenges and strategies
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biologi...
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Article
Open AccessTwo-step success rate criterion strategy: a model- and data-driven partial ambiguity resolution method for medium-long baselines RTK
When GNSS measurement errors such as ionospheric delays remain large, full ambiguity resolution (FAR) takes an unacceptably long time to fix ambiguities to integers. Partial ambiguity resolution (PAR), under t...
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Article
Open AccessNon-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an efficient and safe delivery system into cells and tissues continues to hinder clinical translation of CRISPR approache...
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Article
Complex polymer architectures through free-radical polymerization of multivinyl monomers
The construction of complex polymer architectures with well-defined topology, composition and functionality has been extensively explored as the molecular basis for the development of modern polymer materials....
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Article
Open AccessHighly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
Current therapies for most neurodegenerative disorders are only symptomatic in nature and do not change the course of the disease. Gene therapy plays an important role in disease modifying therapeutic strategi...
