28 Result(s)
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Denise M. Scholtens
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Article
Breast Ductal Lavage for Assessment of Breast Cancer Biomarkers
Lavage of the ductal systems of the breast provides fluid (ductal lavage fluid, DLF) containing hormones and products of hormone actions that may represent more accurately the composition of the breast than sa...
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Open AccessHuman rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects
Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA met...
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Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1
Maternal glucose levels during pregnancy impact the develo** fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but littl...
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Genetics of Gestational Diabetes Mellitus and Maternal Metabolism
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy. Women with a history of GDM are at long-term risk for develo** type 2 diabetes (...
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Nipple Aspirate Fluid Hormone Concentrations and Breast Cancer Risk
Prior reports identify higher serum concentrations of estrogens and androgens as risk factors for breast cancer, but steroids in nipple aspirate fluid (NAF) may be more related to risk. Incident breast cancer ...
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Genome-wide associations for birth weight and correlations with adult disease
Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlat...
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Open AccessSynuclein-γ (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease
Synuclein gamma (SNCG) expression is associated with advanced disease and chemoresistance in multiple solid tumors. Our goal was to determine if SNCG protein expression in ovarian cancer was correlated with cl...
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Open AccessMixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based o...
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Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes
Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediat...
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Open AccessTransversions have larger regulatory effects than transitions
Transversions (Tv’s) are more likely to alter the amino acid sequence of proteins than transitions (Ts’s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the...
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Article
Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads.
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Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study
Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, ind...
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide associatio...
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Open AccessMethylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
Mutations in isocitrate dehydrogenases 1 and 2 (IDHmut) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylat...
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Open AccessVariants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, ...
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Article
Ribosomal protein S11 influences glioma response to TOP2 poisons
Topoisomerase II poisons are one of the most common class of chemotherapeutics used in cancer. We and others had shown that a subset of glioblastomas, the most malignant of all primary brain tumors in adults, ...
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Metabolomic and genetic associations with insulin resistance in pregnancy
Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance.
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Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
We aimed to examine associations of newborn anthropometric measures with childhood glucose metabolism with the hypothesis that greater newborn birthweight, adiposity and cord C-peptide are associated with high...
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Correction to: Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
A Correction to this paper has been published: https://doi.org/10.1007/s00125-021-05421-7
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Article
Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis
Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO r...
