37 Result(s)

Article

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility projec...

Meredith Yeager, Nick Orr, Richard B Hayes, Kevin B Jacobs, Peter Kraft… in Nature Genetics (2007)

Article

Multiple loci identified in a genome-wide association study of prostate cancer

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovaria...

Gilles Thomas, Kevin B Jacobs, Meredith Yeager, Peter Kraft… in Nature Genetics (2008)

Article

Variation in KLK genes, prostate-specific antigen and risk of prostate cancer

Jiyoung Ahn, Sonja I Berndt, Sholom Wacholder, Peter Kraft, Adam S Kibel… in Nature Genetics (2008)

Article

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Stephen Chanock and colleagues report a genome-wide association study of pancreatic cancer. They identify common variants at the ABO blood group locus associated with susceptibility to pancreatic cancer, consi...

Laufey Amundadottir, Peter Kraft, Rachael Z Stolzenberg-Solomon… in Nature Genetics (2009)

Article

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which sh...

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs… in Nature Genetics (2009)

Article

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Stephen Chanock and colleagues identify three new susceptibility loci for pancreatic cancer on chromosomes 13q22.1, 1q32.1 and 5p15.33. The association signal at 13q22.1 maps to a large nongenic region, wherea...

Gloria M Petersen, Laufey Amundadottir, Charles S Fuchs, Peter Kraft… in Nature Genetics (2010)

Article

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Montserrat Garcia-Closas and colleagues report a genome-wide association study for bladder cancer. They identify three new susceptibility loci on chromosomes 22q13.1, 19q12 and 2q37.1.

Nathaniel Rothman, Montserrat Garcia-Closas, Nilanjan Chatterjee… in Nature Genetics (2010)

Article

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.

Mark P Purdue, Mattias Johansson, Diana Zelenika, Jorge R Toro… in Nature Genetics (2011)

Article

Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

Genetic variations in xenobiotic metabolizing genes can influence susceptibility to many environmentally induced cancers. Inheritance of the N-acetyltransferase 1 allele (NAT1*10), linked with increased metabolic...

LaCreis R. Kidd, David W. Hein, Karen Woodson, Philip R. Taylor… in Biochemical Genetics (2011)

Article

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Rosalind Eeles and colleagues report a multistage genome-wide association study of prostate cancer, identifying seven new prostate cancer susceptibility loci.

Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G Giles, Gianluca Severi… in Nature Genetics (2011)

Article

Improved imputation of common and uncommon SNPs with a new reference set

Zhaoming Wang, Kevin B Jacobs, Meredith Yeager, Amy Hutchinson… in Nature Genetics (2012)

Article

Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...

Kevin B Jacobs, Meredith Yeager, Weiyin Zhou, Sholom Wacholder… in Nature Genetics (2012)

Article

Genome-wide association study of glioma and meta-analysis

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for ga...

Preetha Rajaraman, Beatrice S. Melin, Zhaoming Wang… in Human Genetics (2012)

Article

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genoty** array

Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genoty** on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available ...

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders… in Nature Genetics (2013)

Article

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conducti...

Marcel den Hoed, Mark Eijgelsheim, Tõnu Esko, Bianca J J M Brundel… in Nature Genetics (2013)

Article

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

Sonja I Berndt, Christine F Skibola, Vijai Joseph, Nicola J Camp… in Nature Genetics (2013)

Article

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Richard Houlston, Maria Teresa Landi and colleagues report the identification of large-effect associations for squamous lung cancer with rare variants in BRCA2 and CHEK2.

Yufei Wang, James D McKay, Thorunn Rafnar, Zhaoming Wang… in Nature Genetics (2014)

Article

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.

Brian M Wolpin, Cosmeri Rizzato, Peter Kraft, Charles Kooperberg… in Nature Genetics (2014)