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Article
Design of Non-Heat Treatable High Pressure Die Casting Al Alloys: A Review
In recent years, Non-Heat Treatable High Pressure Die Casting Al alloys (NHT-HPDC Al alloys) have been proposed and developed for integrated die casting in the automotive industry. These alloys exhibit excelle...
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Article
PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor
Ventricular remodeling is one of the main causes of mortality from heart failure due to hypertension. Exploring its mechanism and finding therapeutic targets have become urgent scientific problems to be solved...
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Article
3D Gel-Printing of TiC-Reinforced 316L Stainless Steel: Influence of the Printing Parameters
In this paper, the composite composed of TiC (35 wt.%) reinforced 316L stainless steel matrix was successfully prepared using a 3D gel-printing (3DGP) process. The “step effect” of 3D printing can be reduced u...
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Article
Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice
Hydrogen sulfide (H2S) is involved in diverse physiological functions, such as anti-hypertension, anti-proliferation, regulating ATP synthesis, and reactive oxygen species production. Sirtuin 3 (SIRT3) is a NAD ...
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Article
Knockdown of dishevelled-1 attenuates cyclosporine A-induced apoptosis in H9c2 cardiomyoblast cells
Cyclosporine (CsA) has become a mainstay for immune suppression of organ transplants. It is known that patients receiving CsA manifest increased growth of aggressive cardiotoxicity. We have demonstrated that C...
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Article
Cyclosporin A induces apoptosis in H9c2 cardiomyoblast cells through calcium-sensing receptor-mediated activation of the ERK MAPK and p38 MAPK pathways
The cardiotoxicity of cyclosporine A (CsA) limits its clinical application in extensive and long-term therapies. Our group has shown that CsA induces myocardium cell apoptosis in vivo and increases calcium-sen...
