3 Result(s)
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Davide Prandi
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRole of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients i...
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Article
Open AccessPatient derived organoids to model rare prostate cancer phenotypes
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or...
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Article
Open AccessHit and go CAS9 delivered through a lentiviral based self-limiting circuit
In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages. Long-term expression of Cas9 increases the number of genomic loci non-specifically cleaved by the nuclease. H...
