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  1. No Access

    Article

    A highly specific SpCas9 variant is identified by in vivo screening in yeast

    Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity.

    Antonio Casini, Michele Olivieri, Gianluca Petris, Claudia Montagna… in Nature Biotechnology (2018)

  2. No Access

    Article

    Clonal evolution of chemotherapy-resistant urothelial carcinoma

    Mark Rubin, Francesca Demichelis and colleagues study the evolution of urothelial carcinomas by performing whole-exome sequencing of tumors collected from patients before and after chemotherapy. They find mark...

    Bishoy M Faltas, Davide Prandi, Scott T Tagawa, Ana M Molina… in Nature Genetics (2016)

  3. No Access

    Article

    Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

    Genome-wide DNA methylation analysis of metastatic biopsies from patients with castration-resistant prostate cancer reveals marked epigenetic differences between samples with adenocarcinoma and neuroendocrine ...

    Himisha Beltran, Davide Prandi, Juan Miguel Mosquera, Matteo Benelli… in Nature Medicine (2016)