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Article
Acceptable performance of blood biomarker tests of amyloid pathology — recommendations from the Global CEO Initiative on Alzheimer’s Disease
Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly increased the need for biomarker confirmation of amyloid pathology...
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Article
Open AccessActive afforestation of drained peatlands is not a viable option under the EU Nature Restoration Law
The EU Nature Restoration Law (NRL) is critical for the restoration of degraded ecosystems and active afforestation of degraded peatlands has been suggested as a restoration measure under the NRL. Here, we dis...
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Article
Clinical Meaningfulness in Alzheimer’s Disease Clinical Trials. A Report from the EU-US CTAD Task Force
Recent positive results of three phase III anti-amyloid monoclonal antibody trials are transforming the landscape of disease-modifying therapeutics for Alzheimer’s disease, following several decades of failure...
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Article
Neuropsychiatric Symptoms in AD: Clinical Trials Targeting Mild Behavioral Impairment: A Report from the International CTAD Task Force
The International CTAD Task Force (TF) addressed challenges related to designing clinical trials for agitation in dementia, presenting accomplishments from the two previous TFs on neuropsychiatric symptoms (NP...
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Article
Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task Force
In randomized clinical trials (RCTs) for Alzheimer’s Disease (AD), cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers are currently used for the detection and monitoring of AD patholog...
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Chapter and Conference Paper
Assessing the Condition of Copper Conductors Using Deep Learning
The timely replacement of in-service overhead electrical conductors in a distribution network is crucial for the reliable operation of the grid. Visually inspecting the conductors is a non-destructive testing ...
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Chapter
Clinical and Diagnostic Anatomy
Cleft and craniofacial surgeons are required to possess an extensive knowledge in embryology and anatomy of the face to properly treat children with facial differences. Cleft lip and palate occurs in about 1/6...
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Article
Open AccessA map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome
Mouse is probably the most important model organism to study mammal biology and human diseases. A better understanding of the mouse genome will help understand the human genome, biology and diseases. However, ...
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Article
Dysfunctional paraspinal muscles in adult spinal deformity patients lead to increased spinal loading
Decreased spinal extensor muscle strength in adult spinal deformity (ASD) patients is well-known but poorly understood; thus, this study aimed to investigate the biomechanical and histopathological properties ...
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Article
An Analysis of the Technical and Economic Influences of Particle Size Control of an Active Pharmaceutical Ingredient
Particle size control is of vital importance to the performance and manufacturability of a solid drug substance used in an oral dosage pharmaceutical product. Numerous options for control are available to engi...
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Article
Open AccessAn in vivo accelerated developmental myelination model for testing promyelinating therapeutics
Therapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple sclerosis. The efficient translation of compounds promoting myelinati...
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Article
Open AccessEnhancing osseointegration and mitigating bacterial biofilms on medical-grade titanium with chitosan-conjugated liquid-infused coatings
Titanium alloys, in particular, medical-grade Ti-6Al-4 V, are heavily used in orthopaedic applications due to their high moduli, strength, and biocompatibility. Implant infection can result in biofilm formatio...
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Article
Open AccessClinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part VII, nerves of the lower limb
To perform a Delphi-based consensus on published evidence on image-guided interventional procedures for peripheral nerves of the lower limb (excluding Morton’s neuroma) and provide clinical indications.
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Article
Open AccessClinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part V, knee
Interventional procedures around the knee are widely adopted for treating different musculoskeletal conditions. A panel of experts from the Ultrasound and Interventional Subcommittees of the European Society o...
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Article
Open AccessClinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part VI, foot and ankle
Clarity regarding accuracy and effectiveness for interventional procedures around the foot and ankle is lacking. Consequently, a board of 53 members of the Ultrasound and Interventional Subcommittees of the Eu...
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Article
Open AccessImaging Luminescence Thermometry to 750 °C for the Heat Treatment of Common Engineering Alloys and Comparison with Thermal Imaging
Accurate temperature measurements are critical in manufacturing, affecting both product quality and energy consumption. At elevated temperatures, non-contact thermometers are often the only option. However, su...
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Article
Open AccessClinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part IV, hip
Image-guided musculoskeletal interventional procedures around the hip are widely used in daily clinical practice. The need for clarity concerning the actual added value of imaging guidance and types of medicat...
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Chapter
Narratives of Non-Compliance in “Tuesday Non-Fishing Day” in Ghana
The call to incorporate culture into fishing activities has received widespread acceptance. It therefore becomes unusual when an aspect of that culture is gradually being eroded through a violation of a custom...
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Chapter and Conference Paper
Exploring the Effect of Recipe Representation on Critique-Based Conversational Recommendation
Diet diversification can facilitate both positive health outcomes and greater enjoyment in food consumption. Case-based recommendation can play an important role to promote a more diverse diet by connecting us...
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Article
Open AccessEuropean colonisation, law, and Indigenous marine dispossession: historical perspectives on the construction and entrenchment of unequal marine governance
European colonisation played a fundamental role in Indigenous marine dispossession and the entrenchment of unequal and state-dominated marine governance regimes across diverse bodies of water. This article cha...
