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  1. No Access

    Article

    Ultrastructural study of lens fiber damages after laser irradiation

    Lens fiber lesion after laser irradiation were studied in the albino rats. Lose of cytoplasmic contrast, pulling apart of intercellular cell junctions and increase of intracellular vesicles were observed.

    David T. Yew, Yau-wa Chan in Radiation and Environmental Biophysics (1978)

  2. No Access

    Article

    Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and alzheimer patients

    This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in the frontal, occipital, and hippocampal cortices of seven normal aging and four Alzheimer’s patients. Significant increase in T...

    Wai ** Li, Woody Y. Chan, Helen W. L. Lai… in Journal of Molecular Neuroscience (1997)

  3. No Access

    Article

    A Rabbit Model of Proliferative Vitreoretinopathy Induced by Injection of Astrocytic Cultures

    1.The objective of this study was to decipher whether proliferation of astrocytes and invasion of astrocytic processes into the retina could contribute to retinal detachment in a rabbit model.

    David T. Yew, **an** Yi, W. Y. Chan, W. K. W. Lam in Cellular and Molecular Neurobiology (1999)

  4. No Access

    Article

    Changes of Cytochemical Markers in the Conjunctival and Corneal Epithelium After Corneal Debridement

    1. The aim of this study was to determine the epithelial changes of the conjunctiva and cornea up to 7 days after corneal debridement and the changes highlighted included (1) proliferation, (2) production of g...

    David T. Yew, T. K. Lam, D. Tsang, Y. K. Au… in Cellular and Molecular Neurobiology (2000)

  5. No Access

    Article

    Analysis of Gene Expression Following Sciatic Nerve Crush and Spinal Cord Hemisection in the Mouse by Microarray Expression Profiling

    1. The responses of periphery (PNS) and central nervous systems (CNS) towards nerve injury are different: while injured mammalian periphery nerons can successfully undergo regeneration, axons in the central ne...

    Ming Fan, Ruifa Mi, David T. Yew, Wood Yee Chan in Cellular and Molecular Neurobiology (2001)

  6. No Access

    Article

    A Cytological Study on the Development of the Different Types of Visual Cells in the Chicken (Gallus domesticus)

    The formation of visual cells and their intracellular organelles was studied in the embryonic chicken (Gallus domesticus) between stage 36 and hatching. Cilia formation was observed at stage 30 and by stage 42, o...

    Sen Mun Wai, David T. Yew in Cellular and Molecular Neurobiology (2002)

  7. No Access

    Article

    Novel Identification of the Different Types of Cones in the Retina of the Chicken

    1. Although single cones and double cones in the chicken retina had been documented for more than 30 years, the exact morphology of these cells had never been studied by the scanning electronmicroscopy. In thi...

    Sen Mun Wai, Lai Sin Kung, David T. Yew in Cellular and Molecular Neurobiology (2002)

  8. No Access

    Article

    Distribution of Neuropeptide Y-Immunoreactive Neurons in the Human Brainstem, Cerebellum, and Cortex During Development

    1. Neuropeptide Y is found throughout the central nervous system where it appears to play a wide range of often poorly understood functions. In this study, the distribution of neuropeptide Y immunoreactive (NP...

    Sen Mun Wai, Pawel M. Kindler, Edward T. K. Lam… in Cellular and Molecular Neurobiology (2004)

  9. No Access

    Article

    Three-dimensional reconstruction of brain surface anatomy based on magnetic resonance imaging diffusion-weighted imaging: A new approach

    Fifty normal noninfarct patients and 12 cases with infarcts of the cerebrum were examined with routine magnetic resonance imaging and echo-planar diffusion-weighted imaging. The diffusion-weighted three-dimens...

    **angyang Gong, Marong Fang, ** Wang, Jianzhong Sun… in Journal of Biomedical Science (2004)

  10. No Access

    Article

    A fMRI Study of Age-Related Differential Cortical Patterns During Cued Motor Movement

    Healthy adults of three age groups (young, middle-age and older) were cued by a multimedia projector to perform a series of simple (making a fist, opening/closing of the mouth) and complex (opposition of index...

    Marong Fang, Jicheng Li, Gang Lu, **angyang Gong, David T. Yew in Brain Topography (2005)

  11. No Access

    Article

    The Postnatal Development of the Cerebellum— A fMRI and Silver Study

    The aim of this study was to evaluate the postnatal development of the cerebella of the pig and to compare this with the activation of the fMRI. The cells in the cerebella were studied by silver technique and ...

    Marong Fang, Lihong Zhang, Jicheng Li, Chunmei Wang… in Cellular and Molecular Neurobiology (2005)

  12. No Access

    Article

    bcl2, bax and nestin in the brains of patients with neurodegeneration and those of normal aging

    This study was conducted by employing specimens from the frontal cortices of Alzheimer, multiple-infarct dementia patients, and those of normal aging (age matched to patients). The objective was to evaluate an...

    Gang Lu, W. H. Kwong, Qi Li, **cai Wang… in Journal of Molecular Neuroscience (2005)

  13. Article

    Open Access

    Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients

    It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have...

    Dietrich E Lorke, Gang Lu, Eric Cho, David T Yew in BMC Neuroscience (2006)

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  14. No Access

    Article

    Changes of brain activity in the aged SAMP mouse

    This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for fu...

    Lihong Zhang, Qi Li, Lucille T. Wolff, Gregory E. Antonio… in Biogerontology (2007)

  15. No Access

    Article

    Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice

    Senescence-accelerated mice (SAM) strains are useful models to understand the mechanisms of age-dependent degeneration. In this study, measurements of the mitochondrial membrane potential (Δψm) of platelets and t...

    Jie Xu, Chun Shi, Qi Li, Jiajia Wu… in Journal of Bioenergetics and Biomembranes (2007)

  16. No Access

    Article

    Effects of genistein on hippocampal neurodegeneration of ovariectomized rats

    To investigate the mechanism underlying the neurodegeneration of postmenopausal women, the effect of genistein on hippocampal neurodegeneration was investigated in ovariectomized (OVX) Sprague-Dawley rats. Thr...

    Jie Xu, Jianhua Zhu, Chun Shi, Kaihua Guo… in Journal of Molecular Neuroscience (2007)

  17. No Access

    Article

    Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP8)

    The cerebella of SAMP8 (accelerated aging mouse) and SAMR1 controls were analyzed by Western Blotting of tyrosine hydroxylase and choline acetyltransferase, as well as by TUNEL and histological silver staining. B...

    Yonghong Zhu, Cleo C. L. Lee, W. P. Lam, Maria S. M. Wai, John A. Rudd… in Biogerontology (2007)

  18. No Access

    Article

    α-Crystallin Protected Axons from Optic Nerve Degeneration After Crushing in Rats

    In mature mammals, optic nerve injury results in apoptosis of retinal ganglion cells. The literature confirms that lens injury enhances retinal ganglion cells survival, but the mechanism is not very clear. Usi...

    ** Ying, Jia** Zhang, Yanhua Wang, Nan Wu, Yi Wang… in Journal of Molecular Neuroscience (2008)

  19. No Access

    Article

    Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors

    The development of the human insula was studied in the foetuses from 21 to 32 gestation weeks, using silver staining, immunohistochemistry of proliferative cell nuclear antigen (PCNA), activated caspase-3, and...

    Maria S. M. Wai, Chun Shi, W. H. Kwong, Lihong Zhang… in Histochemistry and Cell Biology (2008)

  20. No Access

    Article

    Effects of Gingko Extract (EGb761) on oxidative damage under different conditions of serum supply

    Standardized Ginkgo biloba extract EGb761 is known to have multivalent properties such as anti-oxidation and anti-apoptosis. In this study, we determined in rat pheochromocytoma (PC12) cells effects of EGb761 ...

    Chun Shi, Zhibing Yao, Jie Xu, David T. Yew in Journal of Bioenergetics and Biomembranes (2009)

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