21 Result(s)
within
David T. Yew
English
Cell Biology
-
Article
Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain
Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and reinforcing properties, although recent work has pointed out its antidepressant action following acute exposure....
-
Article
Chronic effects of ketamine on gene expression changes in neurotransmitter receptors and regulators-A PCR-array study
Abuse of ketamine increased rapidly and chronic use of ketamine may result in dependence. We investigated the long-term effects of ketamine on anxiety like behaviors and gene expression changes in neurotransmi...
-
Article
Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis
3-n-Butylphthalide (NBP) is a compound extracted from Chinese celery and is used as an anti-hypertensive herbal medicine for treating stroke patients. The aim of this study is to demonstrate the effects and me...
-
Article
Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals
Serotonin receptor 1A and 2A positive cells in postmortem brainstems were demonstrated via immunohistochemistry in eight control age-matched elderly individuals and eight Alzheimer patients. The 5-HT1A positiv...
-
Article
Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba leaf extracts, has been proposed to exert protective and trophic effects on neurons. However, mechanisms underlying the protective effects of bi...
-
Article
The difference in gliosis induced by β-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains
Astrocytes react to various neurodegenerative insults rapidly and undergo changes known as gliosis or astrogliosis. In Alzheimer’s disease (AD), a wall of reactive astrocytes surrounds senile plaques of β-amyl...
-
Article
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer’s disease patients
Hyperphosphorylation of microtubule associated protein tau had limited studies in Alzheimer’s disease (AD) brainstem. We compared the distribution and number of neurons with hyperphosphorylated tau in two age ...
-
Article
Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors
The development of the human insula was studied in the foetuses from 21 to 32 gestation weeks, using silver staining, immunohistochemistry of proliferative cell nuclear antigen (PCNA), activated caspase-3, and...
-
Article
α-Crystallin Protected Axons from Optic Nerve Degeneration After Crushing in Rats
In mature mammals, optic nerve injury results in apoptosis of retinal ganglion cells. The literature confirms that lens injury enhances retinal ganglion cells survival, but the mechanism is not very clear. Usi...
-
Article
Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP8)
The cerebella of SAMP8 (accelerated aging mouse) and SAMR1 controls were analyzed by Western Blotting of tyrosine hydroxylase and choline acetyltransferase, as well as by TUNEL and histological silver staining. B...
-
Article
Effects of genistein on hippocampal neurodegeneration of ovariectomized rats
To investigate the mechanism underlying the neurodegeneration of postmenopausal women, the effect of genistein on hippocampal neurodegeneration was investigated in ovariectomized (OVX) Sprague-Dawley rats. Thr...
-
Article
Changes of brain activity in the aged SAMP mouse
This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for fu...
-
Article
bcl2, bax and nestin in the brains of patients with neurodegeneration and those of normal aging
This study was conducted by employing specimens from the frontal cortices of Alzheimer, multiple-infarct dementia patients, and those of normal aging (age matched to patients). The objective was to evaluate an...
-
Article
The Postnatal Development of the Cerebellum— A fMRI and Silver Study
The aim of this study was to evaluate the postnatal development of the cerebella of the pig and to compare this with the activation of the fMRI. The cells in the cerebella were studied by silver technique and ...
-
Article
Distribution of Neuropeptide Y-Immunoreactive Neurons in the Human Brainstem, Cerebellum, and Cortex During Development
1. Neuropeptide Y is found throughout the central nervous system where it appears to play a wide range of often poorly understood functions. In this study, the distribution of neuropeptide Y immunoreactive (NP...
-
Article
Novel Identification of the Different Types of Cones in the Retina of the Chicken
1. Although single cones and double cones in the chicken retina had been documented for more than 30 years, the exact morphology of these cells had never been studied by the scanning electronmicroscopy. In thi...
-
Article
A Cytological Study on the Development of the Different Types of Visual Cells in the Chicken (Gallus domesticus)
The formation of visual cells and their intracellular organelles was studied in the embryonic chicken (Gallus domesticus) between stage 36 and hatching. Cilia formation was observed at stage 30 and by stage 42, o...
-
Article
Analysis of Gene Expression Following Sciatic Nerve Crush and Spinal Cord Hemisection in the Mouse by Microarray Expression Profiling
1. The responses of periphery (PNS) and central nervous systems (CNS) towards nerve injury are different: while injured mammalian periphery nerons can successfully undergo regeneration, axons in the central ne...
-
Article
Changes of Cytochemical Markers in the Conjunctival and Corneal Epithelium After Corneal Debridement
1. The aim of this study was to determine the epithelial changes of the conjunctiva and cornea up to 7 days after corneal debridement and the changes highlighted included (1) proliferation, (2) production of g...
-
Article
A Rabbit Model of Proliferative Vitreoretinopathy Induced by Injection of Astrocytic Cultures
1.The objective of this study was to decipher whether proliferation of astrocytes and invasion of astrocytic processes into the retina could contribute to retinal detachment in a rabbit model.
