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  1. No Access

    Article

    Changes of brain activity in the aged SAMP mouse

    This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for fu...

    Lihong Zhang, Qi Li, Lucille T. Wolff, Gregory E. Antonio… in Biogerontology (2007)

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    Article

    Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP8)

    The cerebella of SAMP8 (accelerated aging mouse) and SAMR1 controls were analyzed by Western Blotting of tyrosine hydroxylase and choline acetyltransferase, as well as by TUNEL and histological silver staining. B...

    Yonghong Zhu, Cleo C. L. Lee, W. P. Lam, Maria S. M. Wai, John A. Rudd… in Biogerontology (2007)

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    Article

    Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer’s disease patients

    Hyperphosphorylation of microtubule associated protein tau had limited studies in Alzheimer’s disease (AD) brainstem. We compared the distribution and number of neurons with hyperphosphorylated tau in two age ...

    Maria Sen Mun Wai, Yong Liang, Chun Shi, Eric Y. P. Cho, Hsiang-fu Kung… in Biogerontology (2009)

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    Article

    The difference in gliosis induced by β-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains

    Astrocytes react to various neurodegenerative insults rapidly and undergo changes known as gliosis or astrogliosis. In Alzheimer’s disease (AD), a wall of reactive astrocytes surrounds senile plaques of β-amyl...

    Lanhai Lü, Ying T. Mak, Marong Fang, David T. Yew in Biogerontology (2009)

  5. No Access

    Article

    Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals

    Serotonin receptor 1A and 2A positive cells in postmortem brainstems were demonstrated via immunohistochemistry in eight control age-matched elderly individuals and eight Alzheimer patients. The 5-HT1A positiv...

    L. Y. Yeung, H. F. Kung, David T. Yew in AGE (2010)

  6. No Access

    Article

    Chronic effects of ketamine on gene expression changes in neurotransmitter receptors and regulators-A PCR-array study

    Abuse of ketamine increased rapidly and chronic use of ketamine may result in dependence. We investigated the long-term effects of ketamine on anxiety like behaviors and gene expression changes in neurotransmi...

    Sijie Tan, Ju Zou, Meixiang Li, David T. Yew in Molecular & Cellular Toxicology (2015)