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Article
Chronic effects of ketamine on gene expression changes in neurotransmitter receptors and regulators-A PCR-array study
Abuse of ketamine increased rapidly and chronic use of ketamine may result in dependence. We investigated the long-term effects of ketamine on anxiety like behaviors and gene expression changes in neurotransmi...
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Article
Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals
Serotonin receptor 1A and 2A positive cells in postmortem brainstems were demonstrated via immunohistochemistry in eight control age-matched elderly individuals and eight Alzheimer patients. The 5-HT1A positiv...
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Article
The difference in gliosis induced by β-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains
Astrocytes react to various neurodegenerative insults rapidly and undergo changes known as gliosis or astrogliosis. In Alzheimer’s disease (AD), a wall of reactive astrocytes surrounds senile plaques of β-amyl...
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Article
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer’s disease patients
Hyperphosphorylation of microtubule associated protein tau had limited studies in Alzheimer’s disease (AD) brainstem. We compared the distribution and number of neurons with hyperphosphorylated tau in two age ...
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Article
Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP8)
The cerebella of SAMP8 (accelerated aging mouse) and SAMR1 controls were analyzed by Western Blotting of tyrosine hydroxylase and choline acetyltransferase, as well as by TUNEL and histological silver staining. B...
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Article
Changes of brain activity in the aged SAMP mouse
This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for fu...