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Article
Open AccessBK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation
Mutations of large conductance Ca2+- and voltage-activated K+ channels (BK) are associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific conditional BK knock-out (cKO) mice display ...
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Article
Open AccessSlack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
Mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in ad...
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Article
Open AccessThe Na+-activated K+ channel Slack contributes to synaptic development and plasticity
Human mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (Slack−/−) exhibit cognitive flexibility deficits in distin...
