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5 Result(s)

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  1. No Access

    Article

    p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

    The authors show that myelin, signaling through the receptor p75NTR and its downstream effectors, prevents aberrant sprouting of basal forebrain cholinergic axons in the adult mouse brain.

    Katya J Park, Carlos Ayala Grosso, Isabelle Aubert, David R Kaplan… in Nature Neuroscience (2010)

  2. No Access

    Article

    Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

    Neurogenesis requires a switch of progenitor divisions from symmetrical and self-renewing to asymmetrical. This study shows that the Rho-activating protein Lcf is required for neurogenesis in the murine cortex...

    Andrée Gauthier-Fisher, Dan C Lin, Melissa Greeve, David R Kaplan… in Nature Neuroscience (2009)

  3. No Access

    Article

    Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

    The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain...

    Karun K Singh, Katya J Park, Elizabeth J Hong, Bianca M Kramer… in Nature Neuroscience (2008)

  4. No Access

    Article

    Axon growth inhibition: signals from the p75 neurotrophin receptor

    Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that...

    David R. Kaplan, Freda D. Miller in Nature Neuroscience (2003)

  5. No Access

    Article

    PI-3 kinase and IP3: partners in NT3-induced synaptic transmission

    Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.

    David R. Kaplan, Ellis Cooper in Nature Neuroscience (2001)