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Article
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain
The authors show that myelin, signaling through the receptor p75NTR and its downstream effectors, prevents aberrant sprouting of basal forebrain cholinergic axons in the adult mouse brain.
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Article
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells
Neurogenesis requires a switch of progenitor divisions from symmetrical and self-renewing to asymmetrical. This study shows that the Rho-activating protein Lcf is required for neurogenesis in the murine cortex...
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Article
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain...
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Article
Axon growth inhibition: signals from the p75 neurotrophin receptor
Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that...
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Article
PI-3 kinase and IP3: partners in NT3-induced synaptic transmission
Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.