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Article
Urinary 1-hydroxypyrene in pregnant women in a Northeastern U.S. city: socioeconomic disparity and contributions from air pollution sources
Maternal exposure to polycyclic aromatic hydrocarbons (PAHs), ubiquitous constituents of air pollution, has been associated with adverse birth outcomes. Yet it remains unclear whether and how socioeconomic sta...
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Article
Open AccessChange in rate of healthcare encounters for respiratory infection from air pollution exposure after improved vehicle emissions standards in New York State
The introduction of Tier 3 light-duty vehicles with reduced emissions began in New York State (NYS) in 2017, with required compliance by 2025. We hypothesized that improved air quality during the early impleme...
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Article
Open AccessThe effect of air pollution on the transcriptomics of the immune response to respiratory infection
Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hy...
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Article
Correction to: Term birth weight and ambient air pollutant concentrations during pregnancy, among women living in Monroe County, New York
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessChanges in triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York over time: a case-crossover study
Previous studies have reported that fine particle (PM2.5) concentrations triggered ST elevation myocardial infarctions (STEMI). In Rochester, NY, multiple air quality policies and economic changes/influences from...
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Article
Open AccessTerm birth weight and ambient air pollutant concentrations during pregnancy, among women living in Monroe County, New York
Increased ambient air pollutant concentrations during pregnancy have been associated with reduced birth weight, but the etiologically relevant pregnancy time window(s) is/are unclear. In 76,500 singleton birth...
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Article
Open AccessAmbient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization
Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act...
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Article
Open AccessDo elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?
Previously, we found short-term increases in ambient particulate matter (PM) air pollutant concentrations were associated with increased serum fibrinogen levels in patients with cardiac disease. We now studied...
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Article
Open AccessDaily land use regression estimated woodsmoke and traffic pollution concentrations and the triggering of ST-elevation myocardial infarction: a case-crossover study
Prior work has reported acute associations between ST-elevation myocardial infarction (STEMI) and short-term increases in airborne particulate matter. Subsequently, the association between STEMI and hourly mea...
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Article
Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress
Using data collected before, during, and after the 2008 Summer Olympic Games in Bei**g, this study examines associations between biomarkers of blood coagulation (vWF, sCD62P and sCD40L), pulmonary inflammatio...
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Article
Triggering of ST-elevation myocardial infarction by ambient wood smoke and other particulate and gaseous pollutants
We previously observed increased odds of ST-elevation myocardial infarctions (STEMIs) associated with increased ambient fine particulate matter (PM2.5) in the previous hour. However, data are lacking on the effec...
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Article
Antidepressant use and risk of central nervous system metastasis
Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants, were found to increase central nervous system (CNS) metastasis in mice. Our study investigated in humans whether antidepressants, an...
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Article
Acute changes in ambient temperature are associated with adverse changes in cardiac rhythm
Both increases and decreases in ambient temperature have been associated with increased cardiovascular mortality and morbidity. However, the mechanism(s) remain unclear. We examined associations between biomar...
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Article
Open AccessAmbient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study
We and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known a...
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Chapter and Conference Paper
Evaluating Alternative Exposure Metrics Used for Multipollutant Air Quality and Human Health Studies
Epidemiologic studies of air pollution have traditionally relied upon surrogates of personal pollutant exposures, such as ambient concentration measurements from fixed-site pollutant monitors. This study evalu...
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Article
Refined ambient PM2.5 exposure surrogates and the risk of myocardial infarction
Using a case-crossover study design and conditional logistic regression, we compared the relative odds of transmural (full-wall) myocardial infarction (MI) calculated using exposure surrogates that account for...
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Article
Exposure prediction approaches used in air pollution epidemiology studies: Key findings and future recommendations
Many epidemiologic studies of the health effects of exposure to ambient air pollution use measurements from central-site monitors as their exposure estimate. However, measurements from central-site monitors ma...
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Article
Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress
Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reacti...
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Article
Influence of human activity patterns, particle composition, and residential air exchange rates on modeled distributions of PM2.5 exposure compared with central-site monitoring data
Central-site monitors do not account for factors such as outdoor-to-indoor transport and human activity patterns that influence personal exposures to ambient fine-particulate matter (PM2.5). We describe and compa...
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Article
Variability in the fraction of ambient fine particulate matter found indoors and observed heterogeneity in health effect estimates
Exposure to ambient (outdoor-generated) fine particulate matter (PM2.5) occurs predominantly indoors. The variable efficiency with which ambient PM2.5 penetrates and persists indoors is a source of exposure error...
