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Article
Bayes’ Theorem in Neurocritical Care: Principles and Practice
Patients with critical neurological illness are diverse. As a result of the heterogeneity of this patient population, standardized approaches to patient management might not confer benefit. A precision medicin...
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Article
Open AccessA deep learning model for the classification of atrial fibrillation in critically ill patients
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the intensive care unit and is associated with increased morbidity and mortality. New-onset atrial fibrillation (NOAF) is often initially parox...
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Article
Redefining critical illness
Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond...
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Article
Artificial intelligence in telemetry: what clinicians should know
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Article
Open AccessThe relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients
Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo who...
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Article
Open AccessThe physiological determinants of near-infrared spectroscopy-derived regional cerebral oxygenation in critically ill adults
To maintain adequate oxygen delivery to tissue, resuscitation of critically ill patients is guided by assessing surrogate markers of perfusion. As there is no direct indicator of cerebral perfusion used in rou...
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Article
Open AccessUse of wearable devices for post-discharge monitoring of ICU patients: a feasibility study
Wearable devices generate signals detecting activity, sleep, and heart rate, all of which could enable detailed and near-continuous characterization of recovery following critical illness.
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Article
Open AccessA path to precision in the ICU
Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justificati...
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Mortality Prediction in the ICU
This case study describes how to construct mortality prediction models using typical clinical data available in MIMIC-II. Several predictive models are utilized and compared.
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Article
Open AccessUsing information theory to identify redundancy in common laboratory tests in the intensive care unit
Clinical workflow is infused with large quantities of data, particularly in areas with enhanced monitoring such as the Intensive Care Unit (ICU). Information theory can quantify the expected amounts of total a...
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Article
Open AccessIdentification of sepsis subtypes in critically ill adults using gene expression profiling
Sepsis is a syndromic illness that has traditionally been defined by a set of broad, highly sensitive clinical parameters. As a result, numerous distinct pathophysiologic states may meet diagnostic criteria fo...
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Article
Open AccessBarriers to the effective treatment and prevention of malaria in Africa: A systematic review of qualitative studies
In Africa, an estimated 300-500 million cases of malaria occur each year resulting in approximately 1 million deaths. More than 90% of these are in children under 5 years of age. To identify commonly held beli...
