7 Result(s)
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Article
Open AccessCK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...
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Open AccessHedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas
Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...
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Open AccessFrizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer
Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signa...
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Open AccessDetection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).
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Open AccessSMO expression level correlates with overall survival in patients with malignant pleural mesothelioma
Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...
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Open AccessIdentification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library
Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify n...
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Open AccessEfficacy of Wnt-1 monoclonal antibody in sarcoma cells
Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology of sarcomas are needed as current forms of therapy...
