27 Result(s)
within
David M. Jablons
English
-
Article
Open AccessGenetic and immunologic features of recurrent stage I lung adenocarcinoma
Although surgery for early-stage lung cancer offers the best chance of cure, recurrence still occurs between 30 and 50% of the time. Why patients frequently recur after complete resection of early-stage lung c...
-
Article
Open AccessCase report: recurrent metastatic breast cancer in internal mammary dissection bed discovered at the time of coronary bypass
Many patients who undergo coronary artery bypass surgery have a prior history of cancer and potentially chest radiation which is a known risk factor for coronary atherosclerosis. Prior radiation increases fibr...
-
Article
Open AccessSystematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues
Sequencing key cancer-driver genes using formalin-fixed, paraffin-embedded (FFPE) cancer tissues is becoming the standard for identifying the best treatment regimen. However, about 25% of all samples are rejec...
-
Article
Open AccessFAIM2, as a novel diagnostic maker and a potential therapeutic target for small-cell lung cancer and atypical carcinoid
Lung neuroendocrine (NE) tumors are a heterogeneous group of tumors arising from neuroendocrine cells that includes typical carcinoid, atypical carcinoid, small cell lung cancer (SCLC), and large cell NE cance...
-
Chapter
Lung Cancer Staging and Prognosis
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was developed by the International Association for the Staging of Lung Cancer (IASLC) Lung Cancer Staging Project by a coordinat...
-
Article
Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer
Novel molecular predictive biomarkers for chemotherapy have been screened and validated in non-small cell lung cancer (NSCLC). However, there was no report on the correlation of genome-wide DNA methylation wit...
-
Chapter
Lung Cancer Stem Cells
Lung cancer remains the leading cause of cancer mortality and novel therapies are desperately needed to treat metastatic and recurrent disease. The cancer stem cell hypothesis is based on data that within each...
-
Article
Open AccessCK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...
-
Article
Open AccessHedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas
Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...
-
Article
Open AccessCoumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple human cancers and may therefore be a promising ...
-
Article
Open AccessFrizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer
Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signa...
-
Article
Open AccessDetection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).
-
Article
Open AccessSMO expression level correlates with overall survival in patients with malignant pleural mesothelioma
Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...
-
Chapter
Hallmarks of Metastasis
Metastasis is rarely due to accidental sloughing off of cancerous cells from a nonmalignant tumor and colonizing elsewhere; on the contrary, it is an active process requiring genetic and/or epigenetic mechanis...
-
Chapter
The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation
Increasing research from preclinical and clinical studies is demonstrating that inflammation with its myriad of heterogeneous mediators and cellular effectors plays a role in the malignant initiation of epithe...
-
Article
Open AccessIdentification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library
Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify n...
-
Chapter
Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal
Over the years, the role of the Wingless-int (Wnt) signaling pathway during embryogenesis has been the focus of many researchers, its role being fundamental for physiological organogenesis. More recently, duri...
-
Chapter
Stem Cells and Lung Cancer
Lung cancer with its more than 1 million deaths per year is the leading cause of cancer mortality for both men and women worldwide. Despite recent advances in current treatment modalities, overall survival rat...
-
Article
The role of cancer stem cells in neoplasia of the lung: past, present and future
Through the identification and subsequent targeting of an exquisitely unique and phenotypically defined cancer stem-cell population exhibiting discrete therapeutic vulnerabilities (a potential source of tumor ...
-
Article
Roles of secreted frizzled-related proteins in cancer
The Wnt signaling pathway is implicated in a variety of biological processes ranging from developmental cell fate to human disease. The components involved in Wnt signaling have been under intense investigatio...
