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Article
Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep
Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melat...
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Article
Identification of dimethyldioctadecylammonium ion (m/z 550.6) and related species (m/z 522.6, 494.6) as a source of contamination in mass spectrometry
Chemical contamination can be one of the more common problems encountered when performing trace-level analysis regardless of the analytical technique. Minimizing or eliminating background interferences can be ...
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Article
Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal
The cytotoxic aldehydes 4-hydroxynonenal, 4-hydroperoxynonenal (4-HPNE), and 4-oxononenal are formed during lipid peroxidation via oxidative transformation of the hydroxy or hydroperoxy precursor fatty acids, res...
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Article
Analysis of unsaturated compounds by Ag+ coordination ionspray mass spectrometry: Studies of the formation of the Ag+/lipid complex
Coordination ionspray mass spectrometry (CIS-MS) is a useful tool in the detection and identification of cholesterol ester and phospholipid hydroperoxides and diacyl peroxides. Extensive studies of a series of...
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Chapter
Modeling Short (7 hour)- and Long (6 week)-Term Kinetics of Vitamin B-6 Metabolism with Stable Isotopes in Humans
The significance and relevance of the topics being discussed in this text is under scored by Westerhoff’s (2000) suggestion that biochemistry is poised to make major advances in this century, similar to those ...
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Article
Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla
15R-Prostaglandin E2 (PGE2) methyl ester 15-acetate (1) was isolated from the R-variety of the Caribbean sea whip coral, Plexaura homomalla collected in the Florida Keys. It was present in coral samples from sepa...
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Article
Analysis of diacyl peroxides by Ag+ coordination ionspray tandem mass spectrometry: Free radical pathways of complex decomposition
Organic peroxides have significance in organic synthesis and biological processes. Characterization of these compounds with weak O-O bonds is sometimes difficult due to their thermal instability and sensitivit...
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Article
Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet development
The roles of peroxisomes and microsomes on the biosynthetic pathway for docosahexaenoic acid (DHA) from α-linolenic acid (ALA) were investigated. Microsomes and peroxisomes were prepared from livers of fetal a...
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Article
Mass Spectrometry of Soils Thomas W. Boutton and Shin-ichi Yamasaki, Editors
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Article
Intermediates in Endogenous Synthesis of C22:6ω3 and C20:4ω6 by Term and Preterm Infants
An alternative pathway of ω3 and ω6 fatty acid metabolism has been described in isolated rat hepatocytes and human fibroblasts. This alternative pathway, which is independent of Δ4 desaturation, involves elongati...
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Article
CORRELATION BETWEEN ENDOGENOUS CONVERSION OF 18:3ω3 AND 18:2ω6 IN TERM AND PRETERM INFANTS. ▴ 1902
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Article
CHARACTERIZATION OF PATHWAYS OF ENDOGENOUS SYNTHESIS OF LONG CHAIN POLYUNSATURATED (LC-PUFA) FATTY ACIDS IN PIGLETS. ▴ 1903
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Article
Effect of dietary α-linolenic acid intake on incorporation of docosahexaenoic and arachidonic acids into plasma phospholipids of term infants
The fractional conversion rates of plasma phospholipid α-linolenic acid (18:3n-3) and linoleic acid (18:2n-6) to docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6), respectively, and the fractional ...
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Article
Effects of Infant Nutrition on Cholesterol Synthesis Rates
ABSTRACT: Nutrient effects on cholesterol fractional synthesis rates (FSR) in infancy by stable isotope determination have not been studied. We hypothesized that FSR is significantly reduced with high dietary ...
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Chapter
Stable Isotopes for Measurement of Nutrient Dynamics during Pregnancy and Lactation
Few discoveries in nature have enhanced scientific progress across such a broad expanse of disciplines as have the stable isotopes. Examples of their use can be found in all of the basic and biomedical science...
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Chapter
Metabolism of Apo(a) and ApoB-100 in Human Lipoprotein(a)
Lipoprotein(a) (Lp(a)) is a plasma lipoprotein highly correlated with cardiovascular and cerebrovascular disease. It contains two major proteins: apoB-100 similar to that present in LDL, and apo(a) which exist...
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Article
Origin of Intact Lactoferrin and Its DNA-Binding Fragments Found in the Urine of Human Milk-Fed Preterm Infants. Evaluation by Stable Isotopic Enrichment
ABSTRACT: The origin of intact (78-kD) lactoferrin found in the urine of human milk-fed preterm infants was investigated using human milk containing proteins enriched with [13C]leucine and [15N2]lysine or [2H4]ly...
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Article
Human Lactation II: Endogenous Fatty Acid Synthesis by the Mammary Gland
ABSTRACT: We studied the effects of a diet that was low in fat, high in carbohydrate (CHO) on milk lipid composition and de novo endogenous fatty acid synthesis by the mammary gland in five lactating women. Th...
