9 Result(s)

Article

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of diabetes...

Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves… in Nature Communications (2023)

Article

Author Correction: PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release

Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford… in Nature Communications (2021)

Article

PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturi...

Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford… in Nature Communications (2021)

Article

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine… in Nature Communications (2020)

Article

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the us...

Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine… in Nature Communications (2020)

Article

Remote control of glucose homeostasis in vivo using photopharmacology

Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we ...

Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu… in Scientific Reports (2017)

Article

Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons

Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neur...

Guillaume Osterstock, Violeta Mitutsova, Alexander Barre… in Scientific Reports (2016)

Article

Optical control of insulin release using a photoswitchable sulfonylurea

Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (K_ATP) channels, sulfonylureas boost insulin release from the pancreatic ...

Johannes Broichhagen, Matthias Schönberger, Simon C. Cork… in Nature Communications (2014)

Article

Existence of long-lasting experience-dependent plasticity in endocrine cell networks

Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental condition...

David J. Hodson, Marie Schaeffer, Nicola Romanò, Pierre Fontanaud… in Nature Communications (2012)