9 Result(s)
within
David J. Fink
Neurology
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Article
Open AccessPost-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1
Type B GABA receptors (GABA Rs) play a critical role in synaptic transmission. We carried out studies to determine whether neuronal cell surface expression of GABAB-Rs might be regulated by the Nogo receptor 1...
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Article
Correction: Progress in gene therapy for neurological disorders
Nat. Rev. Neurol. 9, 277–291 (2013); doi:10.1038/nrneurol.2013.56 In the version of this article initially published, HSV-1‒thymidine kinase was incorrectly referred to as tyrosine kinase in Table 4, and as HS...
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Article
Progress in gene therapy for neurological disorders
Neurological diseases that result from an underlying genetic mutation or from acquired genetic and/or epigenetic changes are prevalent in the population, and might be amenable to gene therapy. In this Review, ...
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Open AccessReduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
Painful neuropathy is a common complication of diabetes. Previous studies have identified significant increases in the amount of voltage gated sodium channel isoforms NaV1.7 and NaV1.3 protein in the dorsal root ...
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Article
Open AccessGlial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms of peripheral neuropathy, affecting about 30% of people with acquired immune deficiency syndrome (AIDS). The symptoms of HIV-SN are do...
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Article
Open AccessHSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
To examine the role of inflammatory mediators in neuropathic pain, we used a replication-defective genomic herpes simplex virus (HSV)-based vector containing the coding sequence for the anti-inflammatory pepti...
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Article
Therapeutic gene transfer to the nervous system using viral vectors
The past few years have been marked by substantial progress in preclinical studies of therapeutic gene transfer for neurologic disease using viral-based vectors. In this article, the authors review the data re...
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The relationship of herpes simplex virus latency associated transcript expression to genome copy number: A quantitative study using laser capture microdissection
To investigate the quantitative relationship of latent herpes simplex virus (HSV) genomes to the expression of latency associated transcripts (LATs) we used a combination of laser capture microdissection (LCM)...
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Article
HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system
The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We exam...
