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  1. Article

    Open Access

    Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1

    Type B GABA receptors (GABA Rs) play a critical role in synaptic transmission. We carried out studies to determine whether neuronal cell surface expression of GABAB-Rs might be regulated by the Nogo receptor 1...

    Rachana Murthy, Jeeyong Kim, **ankui Sun, Roman J Giger, David J Fink… in Molecular Brain (2013)

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  2. No Access

    Reference Work Entry In depth

    Opioids and Gene Therapy

    David J. Fink in Encyclopedia of Pain (2013)

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    Article

    Therapeutic gene transfer to the nervous system using viral vectors

    The past few years have been marked by substantial progress in preclinical studies of therapeutic gene transfer for neurologic disease using viral-based vectors. In this article, the authors review the data re...

    Joseph C. Glorioso, Marina Mata, David J. Fink in Journal of NeuroVirology (2003)

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    Article

    The relationship of herpes simplex virus latency associated transcript expression to genome copy number: A quantitative study using laser capture microdissection

    To investigate the quantitative relationship of latent herpes simplex virus (HSV) genomes to the expression of latency associated transcripts (LATs) we used a combination of laser capture microdissection (LCM)...

    **ao-** Chen, Marina Mata, Mary Kelley, Joseph C. Glorioso… in Journal of NeuroVirology (2002)

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    Protocol

    Development of Replication-Defective Herpes Simplex Virus Vectors

    A greater understanding of the molecular, biochemical, and genetic factors involved in the progression of a specific disease state has led to the development of genetic therapies using direct gene transfer to ...

    William F. Goins, David M. Krisky, Darren P. Wolfe, David J. Fink… in Gene Therapy Protocols (2002)

  6. No Access

    Article

    HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system

    The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We exam...

    Marina Mata, Mindi Zhang, **ao** Hu, David J. Fink in Journal of NeuroVirology (2001)

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    Article

    Engineering herpes simplex virus vectors for gene transfer to neurons

    David J. Fink, Joseph C. Giorioso in Nature Medicine (1997)

  8. No Access

    Article

    Modulation of Phosphorylation of Neuronal Cytoskeletal Proteins by Neuronal Depolarization

    1. The neuronal cytoskeletal protein tau and the carboxy tails of cytoskeletal proteins neurofilament-M (NF-M) and neurofilament-H (NF-H) are phosphorylated on serine residues by the cyclin-dependent kinase cd...

    Marina Mata, Paul Honegger, David J. Fink in Cellular and Molecular Neurobiology (1997)

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    Chapter

    Neurovirulence of Herpes Simplex Virus Type 1 Accessory Gene Mutants

    A striking feature of the genome of herpes simplex virus (HSV) is that approximately half of the genes are not essential for replication of the virus in cell culture. It might be predicted that many of these a...

    Myron Levine, David J. Fink… in Pathogenicity of Human Herpesviruses due t… (1994)

  10. No Access

    Chapter

    Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System

    Advances in understanding the molecular basis of human disease in the past decade have led to the identification and cloning of genes responsible for certain heritable diseases of the central nervous system (C...

    Joseph C. Glorioso, Neal A. DeLuca, William F. Goins, David J. Fink in Gene Therapeutics (1994)

  11. No Access

    Article

    Differential distribution of (Na, K)-ATPaseα isoforms in the central nervous system

    1. mRNA transcripts for three isoforms of theα subunit of (Na, K)-ATPase have been previously identified in the ...

    Virginia Hieber, George J. Siegel, David J. Fink… in Cellular and Molecular Neurobiology (1991)