13 Result(s)
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Article
Open AccessAssessing the importance of primary care diagnoses in the UK Biobank
The UK Biobank has made general practitioner (GP) data (censoring date 2016–2017) available for approximately 45% of the cohort, whilst hospital inpatient and death registry (referred to as “HES/Death”) data a...
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Article
Open AccessAdventures in the environment and genes
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Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues
In post-menopausal women, high body mass index (BMI) is an established breast cancer risk factor and is associated with worse breast cancer prognosis. We assessed the associations between BMI and gene expressi...
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What is in a name? Does cancer subty** help or hinder in epidemiology research?
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Article
Open AccessHip Osteoarthritis: Etiopathogenesis and Implications for Management
Highly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of disease. Guidelines for the management of hip OA are often extrapolated from knee OA research, despite clear differences in...
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Article
Interactions between breast cancer susceptibility loci and menopausal hormone therapy in relationship to breast cancer in the Breast and Prostate Cancer Cohort Consortium
Current use of menopausal hormone therapy (MHT) has important implications for postmenopausal breast cancer risk, and observed associations might be modified by known breast cancer susceptibility loci. To prov...
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Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma
Previous studies have shown an inverse association between allergies and glioma risk; however, results for associations between single nucleotide polymorphisms (SNPs) of allergy-related genes and glioma risk h...
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Article
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
Mistakes in DNA repair can result in sustained damage and genetic instability. We comprehensively evaluated common variants in DNA repair pathway genes for their association with postmenopausal breast cancer r...
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Article
Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
Purpose We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk. Methods In this nested case–control study of 239 prospectively ascertained premenopausal breast can...
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Article
A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). A single nucleotide polymorphism (SNP) G-463A in t...
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Article
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma
The frequency of CYP1B1 polymorphisms in pancreatic cancer has never been reported. There is also no evidence on the relationship between CYP1B1 variants and mutations in ras genes (K-, H- or N-ras) in any human ...
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Article
Polymorphisms in Steroid Hormone Pathway Genes and Mammographic Density
Mammographic density has been linked with exposure to endogenous and exogenous steroid hormones, and increased breast cancer risk. Variation in breast density may be due, in part, to polymorphisms in steroid h...
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Chapter
Dietary Guidelines
There are five-fold differences in breast cancer incidence rates around the world [1], and migrants moving from low- to high-incidence countries acquire rates close to those of the new country after one genera...
