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  1. Article

    Open Access

    Vascular compactness of unruptured brain arteriovenous malformation predicts risk of hemorrhage after stereotactic radiosurgery

    The aim of the study was to investigate whether morphology (i.e. compact/diffuse) of brain arteriovenous malformations (bAVMs) correlates with the incidence of hemorrhagic events in patients receiving Stereota...

    Po-Wei Huang, Syu-Jyun Peng, David Hung-Chi Pan, Huai-Che Yang in Scientific Reports (2024)

  2. No Access

    Article

    Improved survival and intracranial tumor control of EGFR-mutated NSCLC patients with newly developed brain metastases following stereotactic radiosurgery and EGFR-TKI: a large retrospective cohort study and meta-analyses

    To examine the differential effects of SRS and TKI on EGFR-mutated NSCLC patients with brain metastases (BMs) and outcomes following continuation of the same TKI agent in case of new BMs.

    Ai Seon Kuan, Chi-Lu Chiang, Hsiu-Mei Wu, Huai-Che Yang in Journal of Neuro-Oncology (2023)

  3. No Access

    Article

    Stereotactic radiosurgery for pituitary and cavernous sinus metastases

    Metastases extending to the pituitary gland and cavernous sinus are extremely rare; however, advances in neuroimaging have increased the reported incidence. Stereotactic radiosurgery (SRS) affords the precise ...

    Yen-Yu Lin, Hsiu-Mei Wu, Huai-Che Yang, Ching-Jen Chen in Journal of Neuro-Oncology (2023)

  4. No Access

    Article

    Natural history of lung squamous cell brain metastases in patients treated with radiosurgery: a thirty-year experience at a tertiary medical center

    In this study we report our 30-year experience in stereotactic radiosurgery (SRS) treatment of lung squamous cell carcinoma (LUSC) brain metastases (BMs). It will serve to provide detailed longitudinal outcome...

    Yu-Chi Chen, Huai-Che Yang, Chi-Lu Chiang, Ching-Jen Chen in Journal of Neuro-Oncology (2023)

  5. No Access

    Article

    Leukoencephalopathy in patients with brain metastases who received radiosurgery with or without whole brain radiotherapy

    Whole brain radiation therapy (WBRT) for brain metastases (BMs) is a common cause of radiation-induced leukoencephalopathy; however the safety of alternative stereotactic radiosurgery (SRS) remains unclear. Th...

    Chan-Wei Liu, Huai-Che Yang, Chi-Lu Chiang, Chia-I. Shen in Journal of Neuro-Oncology (2023)

  6. No Access

    Article

    EGFR mutant status and tyrosine-kinase inhibitors affect the GKRS outcomes for NSCLC brain metastases

    Tyrosine kinase inhibitors (TKIs) is the first-line treatment for EGFR-positive non-small cell lung cancer (NSCLC); however, its applicability to patients with wild-type NSCLC remains an issue of contention. T...

    Hung-Ruei Liao, Chi-Lu Chiang, Chia-I. Shen, Ching-Jen Chen in Journal of Neuro-Oncology (2022)

  7. No Access

    Article

    Stereotactic gamma knife radiosurgery for orbital cavernous hemangioma: clinical outcome and visual function protection

    Although rare, orbital cavernous hemangioma (OCH) is the most common benign orbital neoplasm in adults and may cause vision disturbance or loss due to optic nerve compression. The conventional treatment is sur...

    Hsien-Chung Chen, Chaur-Jong Hu, David Hung-Chi Pan in Journal of Neuro-Oncology (2021)

  8. No Access

    Article

    Repeated gamma knife radiosurgery enables longer tumor control in cases of highly-recurrent intracranial ependymoma

    Stereotactic radiosurgery (SRS) is a potential re-irradiation treatment for recurrent intracranial ependymoma after prior radiation therapy. The purpose of this study was to examine the efficacy and safety of ...

    Yen-Yu Lin, Hsiu-Mei Wu, Huai-Che Yang, Ching-Jen Chen in Journal of Neuro-Oncology (2020)

  9. No Access

    Article

    Radiomics as prognostic factor in brain metastases treated with Gamma Knife radiosurgery

    Gamma Knife radiosurgery (GKRS) is a non-invasive procedure for the treatment of brain metastases. This study sought to determine whether radiomic features of brain metastases derived from pre-GKRS magnetic re...

    Chih-Ying Huang, Cheng-Chia Lee, Huai-Che Yang, Chung-Jung Lin in Journal of Neuro-Oncology (2020)

  10. Article

    Open Access

    Gamma Knife radiosurgery for cerebral cavernous malformation

    This is a retrospective study examining the efficacy and safety of Gamma Knife radiosurgery (GKS) in treating patients with cerebral cavernous malformations (CCMs). Between 1993 and 2018, 261 patients with 331...

    Cheng-Chia Lee, Wei-Hsin Wang, Huai-Che Yang, Chung-Jung Lin in Scientific Reports (2019)

  11. No Access

    Article

    Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes

    To evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of cavernous sinus (CS) meningiomas.

    Yi-Chieh Hung, Cheng-Chia Lee, Wan-Yuo Guo, Cheng-Ying Shiau in Journal of Neuro-Oncology (2019)

  12. No Access

    Article

    Empirical versus progression-guided stereotactic radiosurgery for non-functional pituitary macroadenomas after subtotal resection

    There is a lack of consensus regarding whether if residual non-functional macroadenomas (NFM) should undergo empirical stereotactic radiosurgery (SRS) or be monitored until tumor progression before SRS treatme...

    Cheng-Chia Lee, Huai-Che Yang, Ching-Jen Chen, Chung-Jung Lin in Journal of Neuro-Oncology (2019)

  13. No Access

    Article

    Stereotactic radiosurgery for hypervascular intracranial tumors

    To evaluate the safety and efficacy of SRS treatment of central neurocytomas (CNCs), cavernous sinus hemangiomas (CSHs), and glomus tumors (GTs); and to compare upfront stereotactic radiosurgery (SRS) and adju...

    Cheng-Chia Lee, Chun-Lung Chou, Ching-Jen Chen, Huai-Che Yang in Journal of Neuro-Oncology (2018)

  14. No Access

    Article

    The timing of stereotactic radiosurgery for medically refractory trigeminal neuralgia: the evidence from diffusion tractography images

    Diffusion tensor imaging (DTI) is a novel MRI technique that enables noninvasive evaluation of microstructural alterations in white matter of brain. Initially, DTI was used in intra- or inter-hemispheric assoc...

    Cheng-Chia Lee, Shin Tai Chong, Ching-Jen Chen, Sheng-Che Hung in Acta Neurochirurgica (2018)

  15. No Access

    Chapter and Conference Paper

    Gamma Knife Radiosurgery for the Management of Intracranial Dural Arteriovenous Fistulas

    Background: This report presents our 15-year experience with Gamma Knife radiosurgery (GKS) for the treatment of 321 patients with dural arteriovenous fistulas (DAVFs) in different locations.

    David Hung-Chi Pan, Cheng-Chia Lee in Gamma Knife Neurosurgery in the Management… (2013)

  16. No Access

    Chapter

    Cavernous Sinus Hemangiomas Treated with Gamma Knife Surgery

    Cavernous hemangiomas within the cavernous sinus (CS) are a rare group of extra-axial vascular tumors. They share a similar histology with the more common intra-axial cerebral cavernous malformations. However,...

    David Hung-Chi Pan, Wen-Yuh Chung in Tumors of the Central Nervous System, Volu… (2012)

  17. No Access

    Article

    Gamma Knife radiosurgery as a treatment modality for low-grade pediatric brainstem gliomas: report of two cases

    Chih-Hsiang Liao, David Hung-Chi Pan, Huai-Che Yang, Hsiu-Mei Wu in Child's Nervous System (2012)

  18. No Access

    Article

    Delayed microsurgery for vestibular schwannoma after gamma knife radiosurgery

    Stereotactic radiosurgery for vestibular schwannomas (VSs) has become popular during the last decade with promising clinical results after long-term follow-up. However, on rare occasions, some cases have neede...

    Cheng-Chia Lee, Yu-Shu Yen, David Hung-Chi Pan, Wen-Yuh Chung in Journal of Neuro-Oncology (2010)