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  1. Article

    Open Access

    Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

    Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1...

    Sara H. Isakson, Anthony E. Rizzardi, Alexander W. Coutts… in Communications Biology (2018)

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    Article

    Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation

    The neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called merlin, whose growth-suppressive function is dependent on its ability to form interactions through...

    **aoling Tang, Sung-Wuk Jang, Xuerong Wang, Zhixue Liu… in Nature Cell Biology (2007)

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    Article

    Tumor suppressor gene regulation of cell growth

    The development of cancer involves a myriad of genetic changes that impact on multiple processes important for the orderly regulation of cell growth and differentiation. Genes whose protein products are disrup...

    Erik J. Uhlmann, David H. Gutmann in Cell Biochemistry and Biophysics (2001)