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Article
Open AccessSignature maps for automatic identification of prostate cancer from colorimetric analysis of H&E- and IHC-stained histopathological specimens
Prostate cancer (PCa) is a major cause of cancer death among men. The histopathological examination of post-surgical prostate specimens and manual annotation of PCa not only allow for detailed assessment of di...
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Article
Open AccessGenetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1...
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Article
Open AccessQuantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer
Digital image analysis offers advantages over traditional pathologist visual scoring of immunohistochemistry, although few studies examining the correlation and reproducibility of these methods have been perfo...
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Article
Open AccessEvaluation of protein biomarkers of prostate cancer aggressiveness
Prognostic multibiomarker signatures in prostate cancer (PCa) may improve patient management and provide a bridge for develo** novel therapeutics and imaging methods. Our objective was to evaluate the associ...
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Article
Open AccessQuantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring
Immunohistochemical (IHC) assays performed on formalin-fixed paraffin-embedded (FFPE) tissue sections traditionally have been semi-quantified by pathologist visual scoring of staining. IHC is useful for valida...
