5 Result(s)
within
David Gatfield
Life Sciences
English
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Article
A novel mode of RBD-protein recognition in the Y14–Mago complex
Y14 and Mago are conserved eukaryotic proteins that associate with spliced mRNAs in the nucleus and remain associated at exon junctions during and after nuclear export. In the cytoplasm, Y14 is involved in mRN...
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Article
Open AccessTranslational contributions to tissue specificity in rhythmic and constitutive gene expression
The daily gene expression oscillations that underlie mammalian circadian rhythms show striking differences between tissues and involve post-transcriptional regulation. Both aspects remain poorly understood. We...
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Article
Open AccessI(nsp1)ecting SARS-CoV-2–ribosome interactions
While SARS-CoV-2 is causing modern human history’s most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Tw...
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Protocol
Recording of Diurnal Gene Expression in Peripheral Organs of Mice Using the RT-Biolumicorder
There is high interest in investigating the daily dynamics of gene expression in mammalian organs, for example, in liver. Such studies help to elucidate how and with what kinetics peripheral clocks integrate c...
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Article
Open AccessDiurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms
Cellular iron homeostasis is regulated by iron regulatory proteins (IRP1 and IRP2) that sense iron levels (and other metabolic cues) and modulate mRNA translation or stability via interaction with iron regulat...
