9 Result(s)

Article

Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities

Recent evidence has implicated perituberal, MRI-normal brain tissue as a possible source of seizures in tuberous sclerosis complex (TSC). Data on aberrant structural features in this area that may predispose t...

Alexander A Sosunov, Robert A McGovern… in Acta Neuropathologica Communications (2015)

Article

Preventing Early Bouncebacks to the Neurointensive Care Unit: A Retrospective Analysis and Quality Improvement Pilot

Early unplanned readmissions of “bouncebacks” to intensive care units are a healthcare quality metric and result in higher mortality and greater cost. Few studies have examined bouncebacks to the neurointensiv...

David G. Coughlin, Monisha A. Kumar, Neha N. Patel… in Neurocritical Care (2018)

Article

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected n...

Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann… in Nature Communications (2022)

Article

Selective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer’s disease

David G. Coughlin, Vanessa S. Goodwill, Heidi G. Standke… in Acta Neuropathologica (2022)

Article

Fluid and Biopsy Based Biomarkers in Parkinson’s Disease

Several advances in fluid and tissue-based biomarkers for use in Parkinson’s disease (PD) and other synucleinopathies have been made in the last several years. While work continues on species of alpha-synuclei...

David G. Coughlin, David J. Irwin in Neurotherapeutics (2023)

Article

Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases

Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s disease tau seeds (i.e. 3R/4R) correlate with histolo...

Matteo Manca, Heidi G. Standke, Danielle F. Browne… in Acta Neuropathologica (2023)

Article

TDP43 pathology in chronic traumatic encephalopathy retinas

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neu...

Ragini Phansalkar, Vanessa S. Goodwill… in Acta Neuropathologica Communications (2023)

Article

Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology

Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer’s pathologies, and substantia nigra neuron loss. Nigral neuron loss is associated with parkinsonism in LBD,...

Ece Bayram, David G. Coughlin, Ravi Rajmohan, Irene Litvan in Biology of Sex Differences (2024)