4 Result(s)

Article

TDP43 pathology in chronic traumatic encephalopathy retinas

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neu...

Ragini Phansalkar, Vanessa S. Goodwill… in Acta Neuropathologica Communications (2023)

Article

Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases

Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s disease tau seeds (i.e. 3R/4R) correlate with histolo...

Matteo Manca, Heidi G. Standke, Danielle F. Browne… in Acta Neuropathologica (2023)

Article

Selective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer’s disease

David G. Coughlin, Vanessa S. Goodwill, Heidi G. Standke… in Acta Neuropathologica (2022)

Article

Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities

Recent evidence has implicated perituberal, MRI-normal brain tissue as a possible source of seizures in tuberous sclerosis complex (TSC). Data on aberrant structural features in this area that may predispose t...

Alexander A Sosunov, Robert A McGovern… in Acta Neuropathologica Communications (2015)