6 Result(s)
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David G. Coughlin
Neurosciences
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Article
Open AccessTDP43 pathology in chronic traumatic encephalopathy retinas
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neu...
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Article
Open AccessFluid and Biopsy Based Biomarkers in Parkinson’s Disease
Several advances in fluid and tissue-based biomarkers for use in Parkinson’s disease (PD) and other synucleinopathies have been made in the last several years. While work continues on species of alpha-synuclei...
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Article
Open AccessTau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s disease tau seeds (i.e. 3R/4R) correlate with histolo...
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Article
Open AccessSelective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer’s disease
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Chapter
Progressive Supranuclear Palsy and Corticobasal Degeneration
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative tauopathies with neuronal and glial lesions composed of tau that is composed predominantly of isomers with four re...
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Article
Open AccessEpileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities
Recent evidence has implicated perituberal, MRI-normal brain tissue as a possible source of seizures in tuberous sclerosis complex (TSC). Data on aberrant structural features in this area that may predispose t...
